| アブストラクト | BACKGROUND: Atrial fibrillation is the most common cardiac arrhythmia and a major risk factor for cerebrovascular accident, including ischemic stroke and transient ischemic attack. HYPOTHESIS: Ischemic cerebrovascular accident is associated with increasing age and cardiovascular and cerebrovascular disease in primary care patients with atrial fibrillation. METHODS: Using the U.K. General Practice Research Database, we identified patients with chronic atrial fibrillation who were alive 1 month after initial diagnosis (n = 906). Potential cases of cerebrovascular accident were identified and confirmed by the primary care physician. The incidence of cerebrovascular accident was calculated. A nested case-control analysis was performed to identify factors associated with cerebrovascular accident among patients with chronic atrial fibrillation. RESULTS: During a mean follow-up period of 1.8 years (range: 0-3.9 years), 60 patients with atrial fibrillation were diagnosed with a new cerebrovascular accident (22 cases with transient ischemic attack and 38 with ischemic stroke). The incidence of new cerebrovascular accident was 3.6 per 100 patient-years (95% confidence interval [CI]: 2.8-4.6). Increased age (odds ratios [OR] compared with age 40-69 years: 3.5 [95% CI: 1.2-10.5] for age 70-79 years and 4.9 [95% CI: 1.6-15.0] for age > or = 80 years), prior cerebrovascular event (OR: 3.4; 95% CI: 1.9-6.1) and diabetes (OR: 2.2; 95% CI: 1.0-4.9) were identified as risk factors for a new cerebrovascular accident. CONCLUSIONS: Among patients with atrial fibrillation, risk factors for a new ischemic cerebrovascular accident include previous ischemic stroke or transient ischemic attack, comorbid diabetes, and increasing age. |
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| ジャーナル名 | Clinical cardiology |
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| Pubmed追加日 | 2007/12/12 |
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| 投稿者 | Ruigomez, Ana; Garcia Rodriguez, Luis Alberto; Johansson, Saga; Wallander, Mari-Ann; Edvardsson, Nils |
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| 組織名 | Spanish Centre for Pharmacoepidemiological Research (CEIFE), Madrid, Spain.;aruigomez@ceife.es |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/18069679/ |
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