| アブストラクト | BACKGROUND: There is evidence of an association between decreased bone mineral density, schizophrenia, and prolactin-raising antipsychotic medication. However, it is not known whether this is clinically significant. AIMS: To investigate whether patients with a history of schizophrenia are at increased risk of hip fracture. METHOD: In a case-control study, we compared cases of 'hip fracture' on the General Practice Research Database (n=16,341) with matched controls (n=29,889). RESULTS: Hip fracture was associated with schizophrenia (OR=1.73; 95% CI 1.32-2.28), and prolactin-raising antipsychotics (OR=2.6; 95% CI 2.43-2.78), in the univariate analysis. In the multivariate analysis, prolactin-raising antipsychotics were independently associated with hip fracture but schizophrenia was not. A significant interaction between gender and antipsychotics was foundinthe association with hip fracture (P=0.042); OR=2.12 (95% CI1.73-2.59) for men, OR=1.93 (95% CI1.78-2.10) for women. CONCLUSIONS: The association between prolactin-raising antipsychotic medication and hip fracture may have serious implications for public health. Mental health service patients may require preventive measures including dietary and lifestyle advice. |
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| ジャーナル名 | The British journal of psychiatry : the journal of mental science |
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| Pubmed追加日 | 2007/2/3 |
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| 投稿者 | Howard, Louise; Kirkwood, Graham; Leese, Morven |
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| 組織名 | Health Services Research Department, Institute of Psychiatry, King's College;London SE5 8AF, UK. l.howard@iop.kcl.ac.uk |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/17267929/ |
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