| アブストラクト | Patient data from the National Database of Health Insurance Claims and Specific Health Checkups of Japan (NDB) are used to assess the effect of biguanide administration on rates of lactic acidosis (LA) in hospitalized diabetes mellitus (DM) patients. In this retrospective cohort study (from April 2013 to March 2016), we compare DM inpatients prescribed biguanides to DM inpatients who were not prescribed biguanides to quantify the association between biguanides and incidence of LA. In total, 8,111,848 DM patient records are retrieved from the NDB. Of the 528,768 inpatients prescribed biguanides, 782 develop LA. Of the 1,967,982 inpatients not prescribed biguanides, 1310 develop LA. The rate ratio of inpatients who develop LA and are administered biguanides to those who developed LA without receiving biguanides is 1.44 (95% CI, 1.32-1.58). Incidence rates and rate ratios for both sexes are elevated in the group prescribed biguanides for patients aged 70 years and older, markedly in those 80 years and older: 40.12 and 6.31 (95% CI, 4.75-8.39), respectively, for men and 34.96 and 5.40 (95% CI, 3.91-7.46), respectively, for women. Biguanides should be used conservatively in patients older than 70 years, particularly for those with comorbidities, and with caution in patients 80 years and older. |
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| ジャーナル名 | International journal of environmental research and public health |
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| Pubmed追加日 | 2023/4/14 |
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| 投稿者 | Mohri, Takako; Okamoto, Sawako; Nishioka, Yuichi; Myojin, Tomoya; Kubo, Shinichiro; Higashino, Tsuneyuki; Okada, Sadanori; Akai, Yasuhiro; Noda, Tatsuya; Ishii, Hitoshi; Imamura, Tomoaki |
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| 組織名 | Department of Diabetes and Endocrinology, Nara Medical University Hospital, Nara;634-8522, Japan.;Department of Public Health, Health Management and Policy, Nara Medical;University, Nara 634-8521, Japan.;Education Development Center, Nara Medical University, Nara 634-8521, Japan.;Healthcare and Wellness Division, Mitsubishi Research Institute Inc., Tokyo;100-8141, Japan.;Department of Community-Based Medicine, Nara Medical University, Nara 634-8521,;Japan.;Department of Doctor-Patient Relationships, Nara Medical University, Nara;634-8521, Japan. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/37047916/ |
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