| アブストラクト | Selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs) are reported to cause stress cardiomyopathy (SC). This study evaluated the association between SSRI/SNRI use and the occurrence of cardiomyopathy in the publicly available U.S. Food and Drug Administration Adverse Event Reporting System (FAERS) database. Disproportionate analysis and likelihood ratio tests were used to identify risk associated with SSRIs or SNRIs and the incidence of SC, using data from between from 2012 to 2022 acquired from the FAERS database. The study identified 132 individual case safety reports (ICSRs) of SC associated with SSRIs or SNRIs. Venlafaxine (48%) and fluoxetine (27%) were the most common antidepressants of the ICSRs. Approximately 80% of SC cases were reported in females, with individuals aged 45-65 years identified as a high-risk population. Both venlafaxine (ratio-scale information component [RSIC] 2.54, 95% CI 2.06-3.04) and fluoxetine (RSIC 3.20, 95% CI 2.31-4.47) were associated with SC, with likelihood ratio estimates of 3.55 (p = 0.02) for venlafaxine and 4.82 (p = 0.008) for fluoxetine. The median time to cardiomyopathy onset was 20 days, with hospitalization reported in 48.33% of patients. Venlafaxine and fluoxetine were associated with SC risk, particularly in middle-aged women. Caution should be exercised when using SSRIs or SNRIs combined with other serotonergic medications. |
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| 組織名 | Department of Pharmacy, Shanghai Children's Hospital, Children's Hospital;Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai,;People's Republic of China.;Department of Pharmacy, Hunan Provincial People's Hospital, The First Affiliated;Hospital of Hunan Normal University, Changsha, Hunan, People's Republic of China.;Department of Cardiology, Hunan Provincial People's Hospital, The First;Affiliated Hospital of Hunan Normal University, Changsha, Hunan, People's;Republic of China.;Department of Pharmacy, Guanghua Hospital Affiliated to Shanghai University of;Traditional Chinese Medicine, Shanghai, People's Republic of China.;weihy2001@126.com.;Institute of I Arthritis Research in Integrative Medicine, Shanghai Academy of |
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