| アブストラクト | OBJECTIVE: To evaluate and summarize reports to the Vaccine Adverse Event Reporting System (VAERS), a national spontaneous reporting system, in pregnant people who received a booster dose of mRNA coronavirus disease 2019 (COVID-19) vaccine. METHODS: We searched VAERS for U.S. reports of adverse events in pregnant people who received a booster dose of an mRNA COVID-19 vaccine from September 22, 2021, to March 24, 2022. Clinicians reviewed reports and available medical records. RESULTS: The Vaccine Adverse Event Reporting System received 323 reports of adverse events in pregnant people who received a booster dose of COVID-19 vaccine; 178 (55.1%) after BNT162b2 from Pfizer-BioNTech and 145 (44.9%) after mRNA-1273 from Moderna. Seventy-two (22.3%) reports were coded as serious. One neonatal death was reported, but no maternal deaths occurred. Pregnancy-specific outcomes included 56 (17.3%) spontaneous abortions (before 20 weeks of gestation), eight (2.5%) episodes of vaginal bleeding, five (1.5%) stillbirths (at or after 20 weeks of gestation), four (1.2%) episodes of preeclampsia, and two (0.6%) preterm deliveries. Reporting rates for stillbirth and preterm delivery were below background rates. Ten instances of adverse events in neonates were reported, which included two reports of birth defects. Non-pregnancy-specific adverse events (n=207; 64.1%) were mostly systemic (eg, headache, fatigue) and local reactions and occurred in proportions comparable with those seen in pregnant people who received the primary COVID-19 vaccination series and reported to VAERS during the same period. CONCLUSION: Review of reports after a booster dose of mRNA COVID-19 vaccine in pregnant people in VAERS found their safety profile was comparable with that of published reports after primary COVID-19 vaccination in pregnant people. |
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| ジャーナル名 | Obstetrics and gynecology |
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| Pubmed追加日 | 2022/8/5 |
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| 投稿者 | Moro, Pedro L; Olson, Christine K; Zhang, Bicheng; Marquez, Paige; Strid, Penelope |
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| 組織名 | Immunization Safety Office, Division of Healthcare Quality Promotion, National;Center for Zoonotic and Emerging Infectious Diseases, and the Emergency;Preparedness and Response Team, Field Support Branch, Division of Reproductive;Health, National Center for Chronic Disease Prevention and Health Promotion,;Centers for Disease Control and Prevention, Atlanta, Georgia. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/35926203/ |
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