| アブストラクト | OBJECTIVES: The present study aimed to examine the association between tranexamic acid use and adverse effects (seizures, thromboembolism, and renal dysfunction) in a pediatric trauma population using a national inpatient database in Japan. We also assessed the association between tranexamic acid use and in-hospital mortality. DESIGN: A nationwide, retrospective cohort study using propensity score analyses. SETTING: Japanese Diagnosis Procedure Combination inpatient database. PATIENTS: Pediatric patients less than or equal to 12 years old admitted in hospital with the diagnosis of trauma between July 2010 and March 2014 (n = 61,779). INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Propensity score matching created 1,914 pairs of patients with and without tranexamic acid administration. Propensity-matched analysis showed that the proportion of seizures was significantly higher in the tranexamic acid group than in the nontranexamic acid group (7/1,914, 0.37% vs 0/1,914, 0%; difference, 0.37%; 95% CI, 0.10-0.64; p = 0.008). However, none of the other outcomes were significantly different between the groups. CONCLUSIONS: Tranexamic acid use is associated with a significantly increased risk of seizures. However, no difference exists among any other outcomes between the tranexamic acid and nontranexamic acid groups. |
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| ジャーナル名 | Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies |
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| 投稿日 | 2018/9/11 |
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| 投稿者 | Maeda, Takuma; Michihata, Nobuaki; Sasabuchi, Yusuke; Matsui, Hiroki; Ohnishi, Yoshihiko; Miyata, Shigeki; Yasunaga, Hideo |
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| 組織名 | Department of Anesthesiology, National Cerebral and Cardiovascular Center, Osaka,;Japan.;Division of Transfusion Medicine, National Cerebral and Cardiovascular Center,;Osaka, Japan.;Department of Health Services Research, Graduate School of Medicine, The;University of Tokyo, Tokyo, Japan.;Data Science Center, Jichi Medical University, Shimotsuke, Tochigi, Japan.;Department of Clinical Epidemiology and Health Economics School of Public Health,;The University of Tokyo, Tokyo, Japan. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/30199511/ |
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