| アブストラクト | OBJECTIVES: The present study aimed to examine the association between tranexamic acid (TXA) use and adverse effects (seizures, thromboembolism, and renal dysfunction) in a pediatric cardiac surgery population using a national inpatient database in Japan. The authors also assessed the association between TXA use and other clinical outcomes (length of hospital stay and in-hospital mortality). DESIGN: A nationwide, retrospective cohort study using propensity score analyses. SETTING: Japanese Diagnosis Procedure Combination inpatient database. PARTICIPANTS: Pediatric patients who underwent cardiac surgery using cardiopulmonary bypass between July 2010 and March 2014 (N = 11,275). INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Propensity-score matching created 3,739 pairs of patients with and without TXA administration. Propensity-matched analysis showed that the proportion of seizures was significantly higher in the TXA group than in the non-TXA group (1.6% v 0.2%, difference, 1.4%; 95% confidence interval, 1.0-1.9; p<0.001). However, none of the other outcomes was significantly different between the groups. CONCLUSIONS: TXA use is associated with a significantly increased risk of seizures. However, there is no difference in any other outcomes between the TXA and non-TXA groups. |
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| ジャーナル名 | Journal of cardiothoracic and vascular anesthesia |
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| 投稿日 | 2016/12/19 |
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| 投稿者 | Maeda, Takuma; Sasabuchi, Yusuke; Matsui, Hiroki; Ohnishi, Yoshihiko; Miyata, Shigeki; Yasunaga, Hideo |
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| 組織名 | Department of Anesthesiology, National Cerebral and Cardiovascular Center, Osaka,;Japan; Division of Transfusion Medicine, National Cerebral and Cardiovascular;Center, Osaka, Japan. Electronic address: takuma@ncvc.go.jp.;Department of Health Services Research, Graduate School of Medicine, University;of Tokyo, Tokyo, Japan.;Department of Clinical Epidemiology and Health Economics School of Public Health,;University of Tokyo, Tokyo, Japan.;Japan.;Division of Transfusion Medicine, National Cerebral and Cardiovascular Center,;Osaka, Japan. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/27988092/ |
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