| アブストラクト | BACKGROUND: Transbronchial lung cryobiopsy (TBLC) is a new technique for obtaining high-quality and large-sized lung tissues, as compared to transbronchial forceps biopsy (TBFB), and is useful in the diagnosis of diffuse lung disease (DLD). We aimed to evaluate the safety of TBLC as compared to TBFB in DLD patients in Japan using a nationwide database. METHODS: Data were retrospectively collected from the Japanese Diagnosis Procedure Combination database from April 1, 2020 to March 31, 2022. Eligible patients (n = 9673) were divided into the following two groups: those who underwent TBFB (TBFB group, n = 8742) and TBLC (TBLC group, n = 931). To compare the outcomes between the two groups, a stabilized inverse probability of treatment weighting (IPTW) was applied using propensity scores. The primary outcome was in-hospital mortality, and the secondary outcomes were 28-day mortality, complications (mechanical ventilation, pneumothorax, and bleeding), and length of hospital stay after bronchoscopy. RESULTS: The crude in-hospital mortality rates were 3.2% and 0.9% in the TBFB and TBLC groups, respectively. The stabilized IPTW analysis showed no significant difference in the in-hospital mortality rates between the two groups; the odds ratio of the TBLC group as compared with the TBFB group was 0.73 (95% confidence interval: 0.34-1.60; p = 0.44). Moreover, the secondary outcomes did not significantly differ between the two groups. CONCLUSIONS: TBLC for DLD patients had a similar mortality and complication rates as TBFB. |
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| 投稿者 | Awano, Nobuyasu; Jo, Taisuke; Izumo, Takehiro; Urushiyama, Hirokazu; Matsui, Hiroki; Fushimi, Kiyohide; Watanabe, Hideaki; Yasunaga, Hideo |
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| 組織名 | Department of Respiratory Medicine, Japanese Red Cross Medical Center, 4-1-22;Hiroo, Shibuya-ku, Tokyo 150-8935, Japan. Electronic address:;awanobu0606@hotmail.co.jp.;Department of Health Services Research, Graduate School of Medicine, The;University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8654, Japan; Department of;Respiratory Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1;Hongo, Bunkyo-ku, Tokyo 113-8654, Japan.;Hiroo, Shibuya-ku, Tokyo 150-8935, Japan.;Department of Respiratory Medicine, Graduate School of Medicine, The University;of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8654, Japan.;Department of Clinical Epidemiology and Health Economics, School of Public;Health, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8654, Japan.;Department of Health Policy and Informatics, Tokyo Medical and Dental University;Graduate School of Medicine, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan. |
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