| アブストラクト | OBJECTIVES: The objective of the study was to determine the seasonal changes in the initiation of biological disease-modifying antirheumatic drugs (bDMARDs) and methotrexate (MTX) using big claims data. METHODS: We counted the monthly number of initial administrations of each bDMARD and MTX in patients with rheumatoid arthritis (RA) between April 2010 and March 2017. Data were collected from the National Database of Health Insurance Claims and Specific Health Checkups of Japan. This database covers more than 95% of Japanese citizens. Seasonal changes in the number of initiations were determined. Patient claims were also classified according to drugs, districts, gender, and ages. RESULTS: The initiation of bDMARDs and MTX administration varied according to the season in a sine curve shape, with the highest numbers in May to July and the lowest numbers in November to January. The same changing pattern was observed among each bDMARD, district, gender, and age groups particularly when the number was on the higher side. CONCLUSION: We noted an apparent seasonal change in the number of bDMARDs initiated, with a peak during spring, suggesting an exacerbation of RA in the spring in Japan. These changes are overlooked in daily practice and are only visible using big data. |
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| ジャーナル名 | Modern rheumatology |
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| 投稿日 | 2022/2/16 |
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| 投稿者 | Ando, Fumihiko; Takabayashi, Katsuhiko; Fujita, Shinsuke; Nakajima, Hiroshi; Hanaoka, Hideki; Suzuki, Takahiro |
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| 組織名 | Division of Medical Informatics and Management, Chiba University Hospital, Chiba,;Japan.;Department of Internal Medicine, Sanwa Hospital, Chiba, Japan.;Department of Clinical Design and Medicine, Center for Preventive Medical;Sciences, Chiba University, Chiba, Japan.;Department of Allergy and Clinical Immunology, Chiba University Hospital, Chiba,;Clinical Research Center, Chiba University Hospital, Chiba, Japan. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/35165740/ |
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