| アブストラクト | PURPOSE: Selective oestrogen receptor modulators (SERMs) are a standard treatment for breast cancer and osteoporosis. Alzheimer's disease (AD) is a progressive neurodegenerative disorder that is a serious public health concern. This study aimed to identify potential pharmacovigilance signals related to dementia and AD for SERMs in menopausal and postmenopausal women. METHODS: To investigate this possible association, a disproportionality analysis was performed in VigiBase, the World Health Organization's (WHO) global database of individual case safety reports (ICSRs). Disproportionality was quantified using the reporting odds ratio (ROR). RESULTS: We found risk of reporting dementia for tamoxifen [ROR = 1.74 (1.23-2.45)] and raloxifene [ROR = 1.63 (1.05-2.53)] and AD for raloxifene [ROR = 5.12 (3.26-8.05)]. No statistically significant association was detected for fulvestrant and bazedoxifene with dementia or AD. Most of the reports were severe and affected women over the age of 75. The latency of the reactions was predominantly long, suggesting that dementia is a late-onset reaction. The duration of treatment varied from a few months to more than three years, which may indicate that long-term exposure to SERMs is not necessary to develop dementia associated with these drugs. CONCLUSION: Signals of disproportionate reporting have been observed between the incidence of dementia and AD with SERMs. There are conflicting results from the different studies that have been conducted on the relationship between these drugs and AD. More research is needed to find out what factors determine the risk of cognitive impairment associated with SERMs. |
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| ジャーナル名 | European journal of clinical pharmacology |
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| Pubmed追加日 | 2026/2/18 |
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| 投稿者 | Yuste, Maria Teresa; Badillo, Elena; Galecio, Juan Sebastian; Marin, Pedro |
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| 組織名 | Department of Pharmacology, University of Murcia, Campus de Espinardo, Murcia,;30100, Spain. mariateresa.yuste1@um.es.;30100, Spain.;Escuela de Medicina Veterinaria. Colegio de Ciencias de la Salud, Universidad San;Francisco de Quito, Cumbaya, EC 170157, Ecuador. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/41703146/ |
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