| アブストラクト | Anaphylactic reactions at the time of chimeric antigen receptor T (CAR-T) cell infusion are adverse events that have not been reported in pivotal clinical trials or in real-world series. We report the case of patient with severe anaphylaxis with cardiac arrest after tisagenlecleucel injection for Diffuse Large B cell Lymphoma, who recovered after resuscitation and intensive care treatment; we also conducted a Food and Drug Administration Adverse Event Reporting System database analysis and found several cases of severe anaphlyaxis after CAR-T cell injection. Although not reported in pivotal CAR-T cell studies, anaphylaxis can occur after CAR-T cell injection, highlighting the need to include anaphylaxis as a possible side effect in future studies. |
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| ジャーナル名 | EJHaem |
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| 投稿日 | 2024/6/19 |
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| 投稿者 | Morin, Sarah; Boroli, Filippo; Vandenberghe-Durr, Sophie; Allali, Daniele; Masouridi-Levrat, Stavroula; Chalandon, Yves; Simonetta, Federico |
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| 組織名 | Department of Oncology Division of Hematology Geneva University Hospitals Geneva;Switzerland.;Department of Medicine Faculty of Medicine Translational Research Center for;Oncohematology University of Geneva Geneva Switzerland.;Division of Intensive Care University Hospitals of Geneva and Faculty of;Medicine, University of Geneva Geneva Switzerland.;Department of Medical Specialties Division of Clinical Immunology and Allergy;Geneva University Hospitals Geneva Switzerland. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/38895058/ |
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