| アブストラクト | PURPOSE: To investigate the relationship between antithrombotic agents (antiplatelet agents and anticoagulants) and severe bleeding after percutaneous transhepatic biliary drainage (PTBD) for biliary obstruction, or cholecystostomy for acute cholecystitis. MATERIALS AND METHODS: This retrospective study was institutional review board-approved, and patient consent was waived. Between July 2007 and March 2012, 34 606 patients who underwent PTBD (23 375 patients) or cholecystostomy (11 231 patients) were identified in the Diagnosis Procedure Combination database covering 1119 Japanese hospitals. The association between oral administration of antithrombotic agents prior to the procedure and severe bleeding was evaluated, with adjustment for other potential risk factors, such as age, chronic renal failure, liver cirrhosis, and procedure type. Users of antithrombotic agents were categorized as the continuation group, when they took these agents on the procedure day, or as the discontinuation group, when none were taken. Severe bleeding was defined as bleeding which required red blood cell transfusion or transcatheter arterial embolization within 3 days of the procedure. Univariate and multivariate logistic regression models fitted with generalized estimating equations were performed to evaluate the effect of antithrombotic agents on the bleeding complication. RESULTS: Overall, 780 of 34 606 patients (2.3%) experienced severe bleeding. In the multivariate model, continuation of antiplatelet agents was significantly associated with severe bleeding versus nonuse (odds ratio [OR], 1.87; 95% confidence interval [CI]: 1.14, 3.05; P = .013), whereas discontinuation of antiplatelet agents showed no association (OR, 0.92; 95% CI: 0.70, 1.20; P = .517). The effect of neither continuation nor discontinuation of anticoagulants on severe bleeding was significant. Other significant risk factors for bleeding included older age, chronic renal failure, liver cirrhosis, academic hospital, and PTBD. CONCLUSION: The continuation of antiplatelet agents can increase severe bleeding after percutaneous transhepatic drainage, whereas the effect of continuation of anticoagulants was inconclusive. |
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| ジャーナル名 | Radiology |
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| 投稿日 | 2014/09/10 |
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| 投稿者 | Hamada, Tsuyoshi; Yasunaga, Hideo; Nakai, Yousuke; Isayama, Hiroyuki; Horiguchi, Hiromasa; Fushimi, Kiyohide; Koike, Kazuhiko |
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| 組織名 | From the Department of Gastroenterology, Graduate School of Medicine, University;of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan (T.H., Y.N., H.I., K.K.);;Department of Clinical Epidemiology and Health Economics, School of Public;Health, the University of Tokyo, Tokyo, Japan (H.Y.); Department of Clinical Data;Management and Research, Clinical Research Center, National Hospital Organization;Headquarters, Tokyo, Japan (H.H.); and Department of Health Care Informatics,;Tokyo Medical and Dental University, Tokyo, Japan (K.F.). |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/25203133/ |
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