| アブストラクト | Sexual dysfunctions (SD) are common and debilitating side effects of antipsychotics. The current study analyzes the occurrence of antipsychotic-related SD using data from the US Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS). FAERS was queried for sexual dysfunction adverse events (encoded by 35 different MedDRA preferred terms) secondary to amisulpride, aripiprazole, chlorprothixene, clozapine, haloperidol, loxapine, olanzapine, pipamperone, quetiapine, risperidone, and ziprasidone from 2000 to 2023. Disproportionality signal analysis was performed by calculating the reporting odds ratio (ROR) with its 95% confidence interval (CI). During the observation period, 9203 cases of SD were reported in association with the antipsychotic drug use. Men reported these dysfunctions more frequently (68.4% of all cases) than women. Ziprasidone had the highest ROR for sexual dysfunction in FAERS, at 84.86; 95% CI (77.50, 92.94)) , followed by aripirazole for sexual dysfunction (ROR = 34.17; 95% CI (32.06, 36.43)) . In general, aripiprazole, olanzapine, risperidone, ziprasidone, and quetiapine had higher risk signals across multiple adverse events (AEs), whereas chlorprothixene, loxapine, and amisulpride showed lower risk signals. The pathogenesis of SD does not appear to be limited to specific pathomechanisms and therefore not to specific substances. The differing report distributions by sex and the impact of polypharmacy on the symptoms warrant further investigations. |
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| ジャーナル名 | Naunyn-Schmiedeberg's archives of pharmacology |
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| Pubmed追加日 | 2025/1/11 |
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| 投稿者 | Engel, Johanna; Jeridi, Lamin; Auerbach, Lilly; Zolk, Oliver; Greiner, Timo; Heinze, Martin; Buspavanich, Pichit; Schneider, Michael |
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| 組織名 | University Clinic for Psychiatry and Psychotherapy, Brandenburg Medical School;Immanuel Klinik Rudersdorf, Seebad 82/83, Rudersdorf bei Berlin, 15562,;Rudersdorf, Germany. johanna.engel@mhb-fontane.de.;Rudersdorf, Germany.;Institute of Clinical Pharmacology of the Brandenburg Medical School, Brandenburg;Medical School Immanuel Klinik Rudersdorf, Seebad 82/83, Rudersdorf bei Berlin,;15562, Rudersdorf, Germany.;Research Unit Gender in Medicine, Charite - Universitatsmedizin Berlin, Corporate;Member of Freie Universitat Berlin and Humboldt-Universitat zu Berlin, Berlin,;Germany.;Institute of Sexology and Sexual Medicine, Charite - Universitatsmedizin Berlin,;Corporate Member of Freie Universitat Berlin and Humboldt-Universitat zu Berlin,;Berlin, Germany.;Department of Psychiatry and Neuroscience, Charite - Universitatsmedizin Berlin,;Department of Psychiatry, Psychotherapy and Psychosomatics, Brandenburg Medical;School Theodor Fontane, Neuruppin, Germany.;Faculty of Health Sciences, Joint Faculty of the University of Potsdam, The;Brandenburg Medical School Theodor Fontane and the Brandenburg University of;Technology Cottbus -Senftenberg, Karl-Liebknecht-Str. 24-25, 14476, Potsdam, |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/39797988/ |
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