| アブストラクト | OBJECTIVES: To detect the signals for drospirenone-containing oral contraceptives (DCOCs) and describe the reporting pattern of adverse events (AEs) caused by DCOCs compared with levonorgestrel/desogestrel/gestodene-containing (second/third generation) oral contraceptives. DESIGN: A descriptive analysis of claims data. SETTING: The Korea Institute of Drug Safety & Risk Management-Korea Adverse Event Reporting System Database from 1 February 2008 to 31 December 2017. OUTCOME MEASURES: Signals for DCOCs were identified using three data mining indices. The characteristics, death cases, and the annual pattern of AE reports were compared between DCOCs and second/third generation oral contraceptives. RESULTS: Of the 242 DCOC-related AEs, 54 signals were detected and 10 were identified as new signals that were not included in Korea, US and UK label. The newly detected signals include deep vein thrombophlebitis and frequent urination. Serious AEs were more likely to be reported with DCOCs (7.85%) than with second/third generation oral contraceptives (2.92%). Five deaths after use of DCOCs were reported with vascular AEs, such as pulmonary embolism and thrombosis, whereas one death after use of second/third generation oral contraceptives was reported with the cardiac arrest. CONCLUSIONS: We identified 10 new signals related to DCOCs that were not included in the current label. Additionally, we found higher reports of the deaths and vascular AEs associated with DCOCs than with second/third generation oral contraceptives, which warrants careful monitoring to ensure the safe use of DCOCs. |
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| ジャーナル名 | BMJ open |
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| 投稿日 | 2021/8/15 |
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| 投稿者 | Lee, Yeri; Choi, Ahhyung; Noh, Yunha; Jeon, Ha-Lim; Choe, Seung-Ah; Shin, Ju-Young |
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| 組織名 | School of Pharmacy, Sungkyunkwan University, Suwon, Korea (the Republic of).;Department of Preventive Medicine, College of Medicine, Korea University, Seoul,;Korea (the Republic of).;School of Pharmacy, Sungkyunkwan University, Suwon, Korea (the Republic of);shin.jy@skku.edu.;Department of Clinical Research Design and Evaluation, Samsung Advanced Institute;for Health Sciences and Technology, Seoul, Korea (the Republic of). |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/34389561/ |
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