| アブストラクト | Botulinum toxin is a protein deriving from the bacteria Clostridium botulinum and it is widely used for the treatment of a variety of muscle hyperactivity syndromes and for cosmetic indications. Having a long-lasting effect, Botulinum toxin type A (BTA) is one of the most botulin toxin products used. Even if BTA has shown benefits in reducing the vertical lines between the eyebrows, Adverse Drug Reactions (ADRs) have been experienced as well, of which the most common ones are headache and drooping eyelids. In addition, since other local and systemic risks have been identified, a non-interventional post-authorization safety study (PASS) has been started. The aim of the present study was to report cases of skin toxicity associated with this drug, considering Individual Case Safety Reports (ICSRs) existing on the Eudravigilance website. Among 1464 ICSRs sent to the EV database, 718 ICSRs, including 5154 PTs, reported BTA as a suspected drug associated with cutaneous toxicity. The majority of patients experiencing BTA-induced skin toxicity were female (92.1%) belonging mostly to the age group of 18-64 years. The most serious criteria, when reported, were "Other Medically Important Condition" and "Caused/prolonged hospitalization", although the outcome was mainly reported as "Unknown". The most reported PTs, related to skin disorders, were: "Erythema", "Rash", "Pruritus", "Urticaria", "Swelling face", "Brow ptosis", "Eyelid ptosis", "Injection site pain", and "Angioedema". Considering that in most ICSRs, ADRs related to skin disorders were symptoms of hypersensitivity reactions which in some conditions could be life-threatening, further studies are required to better define the safety profile of BTA used for aesthetic procedures. |
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| ジャーナル名 | Pharmaceuticals (Basel, Switzerland) |
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| 投稿日 | 2023/11/25 |
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| 投稿者 | Nicoletti, Maria Maddalena; Anatriello, Antonietta; Liguori, Valerio; Cantone, Andrea; di Mauro, Gabriella; Izzo, Imma; Lettera, Nicoletta; Della Ragione, Joao Marcos; Campitiello, Maria Rosaria; Cosenza, Vincenzo; Scavone, Cristina |
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| 組織名 | Department of Precision Medicine, University of Campania "Luigi Vanvitelli",;80138 Naples, Italy.;Department of Experimental Medicine, University of Campania "Luigi Vanvitelli",;Regional Center of Pharmacovigilance and Pharmacoepidemiology of Campania Region,;UOC Pharmacy, AORN Santobono Pausilipon Children's Hospital, 80129 Naples, Italy.;Department of Obstetrics and Gynaecology and Physiopathology of Human;Reproduction, ASL Salerno, 84124 Salerno, Italy.;Department of Environmental, Biological and Pharmaceutical Sciences and;Technologies (DiSTABiF), University of Campania "Luigi Vanvitelli", 80138 Naples,;Italy. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/38004476/ |
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