| アブストラクト | PURPOSE: Smoking is a risk factor for some autoimmune diseases, but its association with autoimmune hepatitis remains unknown. We conducted a population-based matched case-control study to examine the association between tobacco smoking and the risk of autoimmune hepatitis in England. PATIENTS AND METHODS: From the Clinical Practice Research Datalink and linked Hospital Episode Statistics, 2005-2017, we included 987 cases diagnosed with autoimmune hepatitis after age 18 years and up to 10 frequency-matched population controls per case. We used multiple logistic regression to estimate the odds ratio of autoimmune hepatitis in ever-smokers vs never-smokers, adjusting for sex, age, general practice, calendar time of registration with the general practice, and socioeconomic status. RESULTS: The autoimmune hepatitis cases were more likely to be ever-smokers than the controls (44% vs 37%). The ever-smokers had an increased risk of autoimmune hepatitis compared with the never-smokers (adjusted odds ratio = 1.20, 95% confidence interval 1.03-1.39). CONCLUSION: Smoking was associated with an increased risk of autoimmune hepatitis. |
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| ジャーナル名 | Clinical epidemiology |
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| 投稿日 | 2024/2/5 |
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| 投稿者 | Gronbaek, Lisbet; Omeife, Harmony; Ban, Lu; Crooks, Colin J; Card, Timothy R; Jepsen, Peter; West, Joe |
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| 組織名 | Department of Hepatology and Gastroenterology, Aarhus University Hospital,;Aarhus, Denmark.;Department of Medicine, Regional Hospital Horsens, Horsens, Denmark.;Lifespan and Population Health, School of Medicine, University of Nottingham,;Nottingham, UK.;National Institute for Health Research (NIHR) Nottingham Biomedical Research;Centre, the Nottingham University Hospitals NHS Trust and University of;Nottingham, Nottingham, UK.;Translational Medical Sciences, School of Medicine, University of Nottingham,;Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/38313042/ |
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