| アブストラクト | PURPOSE: To describe a novel observational study that supplemented primary care electronic health record (EHR) data with sample collection and patient diaries. METHODS: The study was set in primary care in England. A list of 3974 potentially eligible patients was compiled using data from the Clinical Practice Research Datalink. Interested general practices opted into the study then confirmed patient suitability and sent out postal invitations. Participants completed a drug-use diary and provided saliva samples to the research team to combine with EHR data. RESULTS: Of 252 practices contacted to participate, 66 (26%) mailed invitations to patients. Of the 3974 potentially eligible patients, 859 (22%) were at participating practices, and 526 (13%) were sent invitations. Of those invited, 117 (22%) consented to participate of whom 86 (74%) completed the study. CONCLUSIONS: We have confirmed the feasibility of supplementing EHR with data collected directly from patients. Although the present study successfully collected essential data from patients, it also underlined the requirement for improved engagement with both patients and general practitioners to support similar studies. |
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| 組織名 | NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester;University Hospitals NHS Foundation Trust, Manchester Academic Health Science;Centre, Manchester, UK.;Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal;Research, Institute of Inflammation and Repair, Faculty of Medical and Human;Sciences, Manchester Academic Health Science Centre, University of Manchester,;Manchester, UK.;Clinical Practice Research Datalink, Medicines and Healthcare Products Regulatory;Agency, London, UK.;Health eResearch Centre, Farr Institute for Health Informatics Research,;University of Manchester, UK.;Rheumatology Department, Salford Royal NHS Foundation Trust, Salford, UK.;NIHR Manchester Biomedical Research Centre, Central Manchester NHS Foundation;Trust, Manchester Academic Health Science Centre, UK. |
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