| アブストラクト | Pharmacovigilance in food-producing animals is crucial for ensuring the safety of veterinary medicinal products and protecting both animal and public health. Post-marketing safety data for small ruminants remain scarce. This study describes suspected adverse drug reaction (SAR) reports in sheep and goats using the EudraVigilance Veterinary (EVVet) database. Cumulative public data (extracted on 31 December 2025) were obtained for eight active substances with non-sporadic reporting in small ruminants: six antiparasitics (moxidectin, ivermectin, eprinomectin, fenbendazole, toltrazuril, closantel), one antimicrobial (tilmicosin) and one non-steroidal anti-inflammatory drug (meloxicam). Cases were described by species, geographic origin (EEA vs. non-EEA), reporter type, and reaction group (VeDDRA System Organ Class). A Chi-square test on aggregated counts and ratios of species-specific proportions with 95% confidence intervals was used as exploratory, within-database descriptors; no inference on incidence, risk, or underreporting was made. A total of 2075 cases were identified: 1775 (85.5%) in sheep and 300 (14.5%) in goats, the latter close to the goat share of the combined EU sheep and goat population in 2025 (15.6%). Antiparasitics accounted for 85.3% of cases (macrocyclic lactones alone 73.6%). The species distribution differed between therapeutic classes (chi(2)(2) = 37.2, p < 0.001, Cramer's V = 0.13), mainly because of a higher goat share among meloxicam reports (34.3%); the goat share ranged from 3.4% (closantel) to 49.3% (eprinomectin) across substances. The non-EEA share of cases ranged from 11.6% to 82.4%. Veterinarians were the main reporters (80.4-87.7% of cases), and systemic disorders were the most frequent reaction group for every substance. Because exposure denominators, report dates, and animal-level data were not available, these findings describe reporting patterns only and cannot quantify underreporting; they generate hypotheses for studies combining spontaneous reports with species-specific drug utilisation data. |
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| ジャーナル名 | Preventive veterinary medicine |
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| Pubmed追加日 | 2026/11/3 |
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| 投稿者 | Castagna, Fabio; Ruga, Stefano; Musella, Vincenzo; Bava, Roberto; Naccari, Clara; Palma, Ernesto; Britti, Domenico; Liguori, Giovanna |
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| 組織名 | Department of Health Sciences, University "Magna Graecia" of Catanzaro, Catanzaro;88054, Italy.;88054, Italy. Electronic address: roberto.bava@unicz.it.;Local Health Authority (ASL) Foggia, Foggia 71121, Italy. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/42976394/ |
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