| アブストラクト | Psoriasis is a chronic inflammatory skin disease characterized by plaque formation. Interleukin (IL)-23 is upregulated in psoriatic lesions and is thought to be a major regulator of the Th17 pathway in psoriasis pathogenesis. Three monoclonal antibodies targeting the IL-23p19 subunit, guselkumab, tildrakizumab, and risankizumab, have been approved for psoriasis therapy. The balance between cytokines IL-23 and IL-12 can affect antitumor and pro-tumor immune activities, and patients with psoriasis may have higher rates of cancer than the general population. Moreover, a chronic inflammatory state typical of psoriasis may induce protumorigenic effects, however, the potential risk of malignancy in patients taking these drugs remains largely unknown. This study investigated the occurrence of malignancies as suspected adverse reactions (SARs) potentially associated with IL-23 inhibitors by analyzing real-world data from the European EudraVigilance database. Although indicatory, these real-world data seem to confirm the potential association between the IL-23 inhibitors risankizumab and tildrakizumab, and the occurrence of SARs linked to cancer in patients with psoriasis and, according to a gender perspective, they show that this relationship is asymmetrically distributed between women and men, with a clear prevalence of oncologic SARs in men. |
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| ジャーナル名 | Pharmacology research & perspectives |
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| 投稿日 | 2023/8/24 |
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| 投稿者 | Calapai, Fabrizio; Mannucci, Carmen; Cardia, Luigi; Curro, Mariaconcetta; Calapai, Gioacchino; Esposito, Emanuela; Ammendolia, Ilaria |
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| 組織名 | Department of Clinical and Experimental Medicine, University of Messina, Messina,;Italy.;Department of Chemical, Biological, Pharmaceutical and Environmental Sciences,;University of Messina, Messina, Italy.;Department of Biomedical and Dental Sciences and Morphological and Functional;Imaging, University of Messina, Messina, Italy.;Department of Human Pathology of Adult and Childhood "Gaetano Barresi", |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/37615258/ |
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