| アブストラクト | Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is associated with a range of persistent symptoms impacting everyday functioning, known as post-COVID-19 condition or long COVID. We undertook a retrospective matched cohort study using a UK-based primary care database, Clinical Practice Research Datalink Aurum, to determine symptoms that are associated with confirmed SARS-CoV-2 infection beyond 12 weeks in non-hospitalized adults and the risk factors associated with developing persistent symptoms. We selected 486,149 adults with confirmed SARS-CoV-2 infection and 1,944,580 propensity score-matched adults with no recorded evidence of SARS-CoV-2 infection. Outcomes included 115 individual symptoms, as well as long COVID, defined as a composite outcome of 33 symptoms by the World Health Organization clinical case definition. Cox proportional hazards models were used to estimate adjusted hazard ratios (aHRs) for the outcomes. A total of 62 symptoms were significantly associated with SARS-CoV-2 infection after 12 weeks. The largest aHRs were for anosmia (aHR 6.49, 95% CI 5.02-8.39), hair loss (3.99, 3.63-4.39), sneezing (2.77, 1.40-5.50), ejaculation difficulty (2.63, 1.61-4.28) and reduced libido (2.36, 1.61-3.47). Among the cohort of patients infected with SARS-CoV-2, risk factors for long COVID included female sex, belonging to an ethnic minority, socioeconomic deprivation, smoking, obesity and a wide range of comorbidities. The risk of developing long COVID was also found to be increased along a gradient of decreasing age. SARS-CoV-2 infection is associated with a plethora of symptoms that are associated with a range of sociodemographic and clinical risk factors. |
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| 投稿者 | Subramanian, Anuradhaa; Nirantharakumar, Krishnarajah; Hughes, Sarah; Myles, Puja; Williams, Tim; Gokhale, Krishna M; Taverner, Tom; Chandan, Joht Singh; Brown, Kirsty; Simms-Williams, Nikita; Shah, Anoop D; Singh, Megha; Kidy, Farah; Okoth, Kelvin; Hotham, Richard; Bashir, Nasir; Cockburn, Neil; Lee, Siang Ing; Turner, Grace M; Gkoutos, Georgios V; Aiyegbusi, Olalekan Lee; McMullan, Christel; Denniston, Alastair K; Sapey, Elizabeth; Lord, Janet M; Wraith, David C; Leggett, Edward; Iles, Clare; Marshall, Tom; Price, Malcolm J; Marwaha, Steven; Davies, Elin Haf; Jackson, Louise J; Matthews, Karen L; Camaradou, Jenny; Calvert, Melanie; Haroon, Shamil |
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| 組織名 | Institute of Applied Health Research, University of Birmingham, Birmingham, UK.;K.Nirantharan@bham.ac.uk.;Midlands Health Data Research UK, Birmingham, UK. K.Nirantharan@bham.ac.uk.;DEMAND Hub, University of Birmingham, Birmingham, UK. K.Nirantharan@bham.ac.uk.;Centre for Patient-Reported Outcomes Research, Institute of Applied Health;Research, University of Birmingham, Birmingham, UK.;National Institute for Health and Care Research (NIHR) Applied Research;Collaboration (ARC) - West Midlands, Birmingham, UK.;Birmingham Health Partners Centre for Regulatory Science and Innovation,;University of Birmingham, Birmingham, UK.;NIHR Birmingham-Oxford Blood and Transplant Research Unit (BTRU) in Precision;Transplant and Cellular Therapeutics, University of Birmingham, Birmingham, UK.;Clinical Practice Research Datalink, Medicines and Healthcare products Regulatory;Agency, London, UK.;School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham,;Birmingham, UK.;Institute of Health Informatics, Faculty of Population Health Sciences,;University College London, London, UK.;Warwick Medical School, University of Warwick, Coventry, UK.;School of Oral and Dental Sciences, University of Bristol, Bristol, UK.;NIHR Surgical Reconstruction and Microbiology Research Centre, University;Hospital Birmingham and University of Birmingham, Birmingham, UK.;Midlands Health Data Research UK, Birmingham, UK.;DEMAND Hub, University of Birmingham, Birmingham, UK.;Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham,;UK.;NIHR Birmingham Biomedical Research Centre, University Hospital Birmingham and;University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.;Centre for Trauma Science Research, University of Birmingham, Birmingham, UK.;MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research, Institute of;Inflammation and Ageing, University of Birmingham, Birmingham, UK.;PIONEER HDR-UK Data Hub in acute care, University of Birmingham, Birmingham, UK.;UK SPINE, University of Birmingham, Birmingham, UK.;Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham,;Institute for Mental Health, University of Birmingham, Birmingham, UK.;Birmingham and Solihull Mental Health NHS Foundation Trust, Birmingham, UK.;Aparito Ltd, Wrexham, UK.;Patient and public involvement member, Birmingham, UK. |
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