| アブストラクト | Familial hypercholesterolaemia (FH) is a common inherited cause of premature cardiovascular disease, but the majority of patients remain undiagnosed. The aim of this systematic review was to assess the effectiveness of interventions to systematically identify FH in primary care. No randomised, controlled studies were identified; however, three non-randomised intervention studies were eligible for inclusion. All three studies systematically identified FH using reminders (on-screen prompts) in electronic health records. There was insufficient evidence that providing comments on laboratory test results increased the identification of FH using the Dutch Lipid Clinic Network (DLCN) criteria. Similarly, using prompts combined with postal invitation demonstrated no significant increase in definite FH identification using Simon-Broome (SB) criteria; however, the identification of possible FH increased by 25.4% (CI 17.75 to 33.97%). Using on-screen prompts alone demonstrated a small increase of 0.05% (95% CI 0.03 to 0.07%) in identifying definite FH using SB criteria; however, when the intervention was combined with an outreach FH nurse assessment, the result was no significant increase in FH identification using a combination of SB and DLCN criteria. None of the included studies reported adverse effects associated with the interventions. Currently, there is insufficient evidence to determine which is the most effective method of systematically identifying FH in non-specialist settings. |
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| ジャーナル名 | Journal of personalized medicine |
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| 投稿日 | 2021/5/1 |
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| 投稿者 | Silva, Luisa; Qureshi, Nadeem; Abdul-Hamid, Hasidah; Weng, Stephen; Kai, Joe; Leonardi-Bee, Jo |
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| 組織名 | Primary Care Stratified Medicine (PRISM) Group, NIHR School of Primary Care;Research, University of Nottingham, Nottingham NG7 2RD, UK.;Department of Primary Care Medicine, Faculty of Medicine, Universiti Teknologi;MARA, Sungai Buloh 47000, Malaysia.;Centre for Evidence Based Healthcare, Division of Epidemiology and Public Health,;School of Medicine, University of Nottingham, Nottingham NG7 2RD, UK. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/33920869/ |
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