| アブストラクト | OBJECTIVE: To determine the burden of comorbidities in OA and their temporal relationships in the UK. METHODS: The Clinical Practice Research Datalink (CPRD) GOLD was used to identify people with incident OA and age, gender and practice matched non-OA controls from UK primary care. Controls were assigned the same index date as matched cases (date of OA diagnosis). Associations between OA and 49 individual comorbidities and multimorbidities (two or more comorbidities excluding OA) both before and after OA diagnosis were estimated, adjusting for covariates, using odds ratios (aORs) and hazard ratios (aHRs), respectively. RESULTS: During 1997-2017, we identified 221 807 incident OA cases and 221 807 matched controls. Of 49 comorbidities examined, 38 were associated with OA both prior to and following the diagnosis of OA and 2 (dementia and systemic lupus erythematosus) were associated with OA only following the diagnosis of OA. People with OA had a higher risk of developing heart failure [aHR 1.63 (95% CI 1.56, 1.71)], dementia [aHR 1.62 (95% CI 1.56, 1.68)], liver diseases [aHR 1.51 (95% CI 1.37, 1.67)], irritable bowel syndrome [aHR 1.51 (95% CI 1.45, 1.58)], gastrointestinal bleeding [aHR 1.49 (95% CI 1.39, 1.59)], 10 musculoskeletal conditions and 25 other conditions following OA diagnosis. The aOR for multimorbidity prior to the index date was 1.71 (95% CI 1.69, 1.74), whereas the aHR for multimorbidity after the index date was 1.29 (95% CI 1.28, 1.30). CONCLUSIONS: People with OA are more likely to have other chronic conditions both before and after the OA diagnosis. Further study on shared aetiology and causality of these associations is needed. |
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| ジャーナル名 | Rheumatology (Oxford, England) |
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| 投稿日 | 2021/1/29 |
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| 投稿者 | Swain, Subhashisa; Coupland, Carol; Mallen, Christian; Kuo, Chang Fu; Sarmanova, Aliya; Bierma-Zeinstra, Sita M A; Englund, Martin; Prieto-Alhambra, Daniel; Doherty, Michael; Zhang, Weiya |
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| 組織名 | Academic Rheumatology, Division of Rheumatology, Orthopaedics and Dermatology.;Pain Centre and Versus Arthritis, University of Nottingham, Nottingham, UK.;Division of Primary Care, School of Medicine, University of Nottingham,;Nottingham.;School of Medicine, Keele University, Keele, UK.;Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital,;Taoyuan City, Taiwan.;Musculoskeletal Research Unit, Bristol Medical School, Translational Health;Sciences, University of Bristol, Bristol, UK.;Department of General Practice, Department of Orthopaedic Surgery, Erasmus;University Medical Center, Rotterdam, The Netherlands.;Clinical Epidemiology Unit, Orthopaedics, Department of Clinical Sciences, Lund;University, Lund, Sweden.;Centre for Statistics in Medicine, Nuffield Department of Orthopaedics,;Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/33506862/ |
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