| アブストラクト | AIM: To characterize the longitudinal variability of estimated glomerular filtration rate (eGFR) in people with type 2 diabetes mellitus (T2DM), including variation between categories and individuals. METHODS: People with T2DM and sufficient recorded serum creatinine measurements were identified from the Clinical Practice Research Datalink (T2DM diagnosis from 1 January 2009 to 1 January 2011 with 5 years follow-up); eGFR was calculated using the CKD-EPI equation. RESULTS: In total, 7766 individuals were included; 32.8%, 50.2%, 12.4%, 4.0% and 0.6% were in glomerular filtration rate (GFR) categories G1, G2, G3a, G3b and G4, respectively. Overall, eGFR decreased by 0.44 mL/min/1.73 m(2) per year; eGFR increased by 0.80 mL/min/1.73 m(2) between index and year 1, then decreased by 0.75 mL/min/1.73 m(2) annually up to year 5. Category G1 showed a steady decline in eGFR over time; G2, G3a and G3b showed an increase between index and year 1, followed by a decline. Category G4 showed a mean eGFR increase of 1.85 mL/min/1.73 m(2) annually. People in categories G3-G4 moved across a greater number of GFR categories than those in G1 and G2. Individual patients' eGFR showed a wide range of values (change from baseline at year 5 varied from -80 to +59 mL/min/1.73 m(2) ). CONCLUSION: Overall, eGFR declined over time, although there was considerable variation between GFR categories and individuals. This highlights the difficulty in prescribing many glucose-lowering therapies, which require dose adjustment for renal function. The study also emphasizes the importance of regular monitoring of renal impairment in people with T2DM. |
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| ジャーナル名 | Diabetes, obesity & metabolism |
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| 投稿日 | 2019/4/4 |
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| 投稿者 | Spanopoulos, Dionysis; Okhai, Hajra; Zaccardi, Francesco; Tebboth, Abigail; Barrett, Brendan; Busse, Michael; Webb, Joanne; Khunti, Kamlesh |
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| 組織名 | Market Access, Boehringer Ingelheim Ltd, Bracknell, UK.;Diabetes Research Centre, University of Leicester, Leicester, UK.;Medical Affairs, Boehringer Ingelheim Ltd, Bracknell, UK.;Medical Affairs, Eli Lilly and Company, Basingstoke, UK. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/30941882/ |
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