| アブストラクト | Background: The promise of immune checkpoint inhibitors (ICIs) therapy in cancer treatment is tempered by the occurrence of immune-related adverse events (irAEs). Many patients undergoing ICIs also take aspirin, but the association between aspirin and irAEs is not well understood. Methods: This study analyzed adverse reaction data associated with the use of ICIs in the US Food and Drug Administration (FDA) Adverse Event Reporting System FDA Adverse Event Reporting System database, from the approval date of each drug until 1 October 2022. Multivariate logistic regression was employed to assess the association of aspirin use with irAEs in patients receiving ICIs. Results: The results indicated that aspirin use was associated with an increased risk of irAEs in a pan-cancer analysis, with a more pronounced association in specific cancer types such as lung cancer, mesothelioma, and pancreatic cancer. However, in lymphoma, aspirin use was associated with a reduced risk of irAEs. Furthermore, aspirin use was associated with an increased risk of certain irAEs, such as anemia, colitis, myocarditis, myositis, pancreatitis, pericarditis, and pneumonia, while it was associated with a reduced risk of rash, Stevens-Johnson syndrome, and thyroiditis. Conclusion: This study has unveiled an association between aspirin use and irAEs in cancer patients receiving ICIs therapy, emphasizing the need for individualized consideration of patients' medication history when devising cancer treatment plans to enhance efficacy and reduce risks. |
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| ジャーナル名 | Frontiers in pharmacology |
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| 投稿日 | 2023/11/30 |
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| 投稿者 | Yang, Huaju; Liu, Zheran; Li, Ruidan; Huang, Rendong; Peng, Xingchen |
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| 組織名 | Department of Radiation Oncology, Cancer Center, West China Hospital, Sichuan;University, Chengdu, China.;Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University,;Chengdu, China.;Hangzhou Linan Guorui Health Industry Investment Co., Ltd., Hangzhou, China. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/38035011/ |
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