| アブストラクト | BACKGROUND: We aimed to understand the time period of cancer diagnosis and the cancer types detected in primary care patients with unexpected weight loss (UWL) to inform cancer guidelines. METHODS: This retrospective matched cohort study used cancer registry linked electronic health records from the UK's Clinical Practice Research Datalink from between 2000 and 2014. Univariable and multivariable time-to-event analyses examined the association between UWL, and all cancers combined, cancer site and stage. RESULTS: In all, 63,973 patients had UWL recorded, of whom 1375 (2.2%) were diagnosed with cancer within 2 years (days-to-diagnosis: mean 181; median 80). Men with UWL (HR 3.28 (2.88-3.73)) and women (1.87 (1.68-2.08)) were more likely than comparators to be diagnosed with cancer within 3 months. The association was greatest in men aged >/=50 years and women >/=70 years. The commonest cancers were pancreas, cancer of unknown primary, gastro-oesophageal, lymphoma, hepatobiliary, lung, bowel and renal-tract. The majority were late-stage, but there was some evidence of association with stage II and stage III cancers. In the 3-24 months after presenting with UWL, cancer diagnosis was less likely than in comparators. CONCLUSION: UWL recorded in primary care is associated with a broad range of cancer sites of early and late-stage. |
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| ジャーナル名 | British journal of cancer |
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| 投稿日 | 2020/4/16 |
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| 投稿者 | Nicholson, Brian D; Hamilton, Willie; Koshiaris, Constantinos; Oke, Jason L; Hobbs, F D Richard; Aveyard, Paul |
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| 組織名 | Nuffield Department of Primary Care Health Sciences, University of Oxford,;Oxford, OX2 6GG, UK. brian.nicholson@phc.ox.ac.uk.;Medical School, University of Exeter, Exeter, UK.;Oxford, OX2 6GG, UK. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/32291391/ |
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