| アブストラクト | PURPOSE: To study the effect of tricyclic antidepressant (TCA)/selective serotonin-norepinephrine reuptake inhibitor (SNRI) versus selective serotonin reuptake inhibitor (SSRI) on the risk of urinary tract infection (UTI) among people with multiple sclerosis (MS). METHODS: A case-control study was conducted using data from the UK Clinical Practice Research Datalink Aurum, nested within a cohort of people with MS. Each person with a UTI was matched to </= 4 controls on sex, region, age (+/-2 years), and time since MS diagnosis (+/-20%). Conditional logistic regression analyses were conducted to calculate adjusted odds ratios (aORs) with 95% confidence intervals (CIs) to compare TCA/SNRI to SSRI use and each antidepressant group to no antidepressant use. ORs were adjusted for smoking status, BMI, comorbidities, and recent drug prescriptions. RESULTS: Two thousand six hundred and sixty-four cases were matched to 3722 controls. TCA/SNRI versus SSRI use did not increase the risk of UTI (conditional aOR 1.21 [95% CI: 0.84-1.75]). TCA/SNRI use versus no antidepressant use did show an increased risk (conditional aOR [95% CI: 1.43 [1.21-1.69]), but SSRI versus no use did not (conditional aOR 1.15 [0.96-1.37]). CONCLUSIONS: This study showed no increased risk of UTI for TCA/SNRI versus SSRI use among people with MS. However, effect estimates were imprecise due to small sample sizes. |
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| ジャーナル名 | Pharmacoepidemiology and drug safety |
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| Pubmed追加日 | 2025/11/6 |
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| 投稿者 | Leung, Melissa W Y; van de Garde, Ewoudt M W; Uitdehaag, Bernard M J; Souverein, Patrick C; Klungel, Olaf H; Bazelier, Marloes T |
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| 組織名 | Division Pharmacoepidemiology & Clinical Pharmacology, Utrecht Institute for;Pharmaceutical Sciences (UIPS), Department of Pharmaceutical Sciences, Faculty of;Science, Utrecht University, Utrecht, the Netherlands.;Department of Pharmacy, Sint Antonius Hospital, Utrecht/Nieuwegein, the;Netherlands.;Department of Neurology, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam;University Medical Center, Amsterdam, the Netherlands. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/41195597/ |
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