| アブストラクト | INTRODUCTION: Studies in patients with immune-mediated inflammatory diseases (IMIDs) have inconsistently suggested that anti-TNFalpha therapy may be associated with excessive weight gain. AREAS COVERED: We performed a nested case/non-case analysis to investigate the anti-TNF-alpha inhibitor-associated body-changes in the US Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) database. The risk was expressed as a measure of disproportionality using the reporting odds ratio (ROR) while adjusting for sex, drugs known to cause weight gain and reporter type. We also performed a time-to-onset (TTO) analysis of body weight-related events. RESULTS: Infliximab was the most commonly involved TNF-alpha inhibitor in body weight-related changes, reaching an aROR of 1.42 (95%CI:1. 26; 1.59). An increased risk was especially found in patients affected by rheumatic disorders, both in the adult and pediatric population. The median TTO after the start of anti- TNFalpha therapy was about 6-7 months for both children and adults. CONCLUSIONS: Given the potential effect of these agents on the excess weight gain in IMIDs patients, continuous attention for this side effect with appropriate counseling regarding lifestyle modifications are warranted, especially in those at high risk for obesity. |
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| ジャーナル名 | Expert opinion on biological therapy |
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| 投稿日 | 2021/7/1 |
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| 投稿者 | Mazhar, Faizan; Battini, Vera; Gringeri, Michele; Pozzi, Marco; Mosini, Giulia; Marran, Albaraa Mohammed N; Akram, Shahzad; van Manen, Robbert P; Radice, Sonia; Clementi, Emilio; Carnovale, Carla |
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| 組織名 | "Luigi Sacco" University Hospital, Universita Di Milano, Milan, Italy.;Scientific Institute, IRCCS E. Medea, Bosisio Parini, LC, Italy.;Department of Pharmaceutical Care, Prince Mohammed Bin Nasser Hospital, Jizan,;Saudi Arabia.;Pharmaceutical Care Department, King Abdullah Specialist Children Hospital, King;Abdul-Aziz Medical City, National Guard Health Affairs, Riyadh, Saudi Arabia.;Oracle Health Sciences, Kattendijke, The Netherlands. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/34191656/ |
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