The impact of repeated vaccination on relative influenza vaccine effectiveness among vaccinated adults in the United Kingdom.
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アブストラクト Annual seasonal influenza vaccination is recommended for individuals at high risk of developing post-infection complications in many locations. However, reduced vaccine immunogenicity and effectiveness have been observed among repeat vaccinees in some influenza seasons. We investigated the impact of repeated influenza vaccination on relative vaccine effectiveness (VE) among individuals who were recommended for influenza vaccination in the United Kingdom with a retrospective cohort study using primary healthcare data from the Clinical Practice Research Datalink, a primary care database in the United Kingdom. Relative VE was estimated against general practitioner-diagnosed influenza-like illnesses (GP-ILI) and medically attended acute respiratory illnesses (MAARI) among participants who have been repeatedly vaccinated compared with first-time vaccinees using proportional hazards models. Relative VE against MAARI may be reduced for individuals above 65 years old who were vaccinated in the current and previous influenza seasons for some influenza seasons. However, these findings were not conclusive as we could not exclude the possibility of residual confounding in our dataset. The use of routinely collected data from electronic health records to examine the effects of repeated vaccination needs to be complemented with sufficient efforts to include negative control outcomes to rule out residual confounding. ジャーナル名 Epidemiology and infection 投稿日 2022/11/5 投稿者 Lim, Wey Wen; Cowling, Benjamin J; Nakafero, Georgina; Feng, Shuo; Nguyen-Van-Tam, Jonathan S; Bolt, Hikaru 組織名 WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School;of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong;Special Administrative Region, China.;Laboratory of Data Discovery for Health Limited, Hong Kong Science and Technology;Park, New Territories, Hong Kong Special Administrative Region, China.;Academic Rheumatology, Faculty of Medicine and Health Sciences, University of;Nottingham, Nottingham, UK.;Oxford Vaccine Group, University of Oxford, Oxford, UK.;Division of Epidemiology and Public Health, School of Clinical Sciences,;University of Nottingham, Nottingham, UK.;South East and London Field Services, National Infection Service, Public Health;England, London, UK.;Department of Infectious Disease Epidemiology, Faculty of Epidemiology and;Population Health, London School of Hygiene and Tropical Medicine, London, UK. Pubmed リンク https://www.ncbi.nlm.nih.gov/pubmed/36331053/ -
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