| アブストラクト | OBJECTIVES: To determine the incidence of lung cancer amongst primary care referrals for investigation with a chest radiograph (CXR). METHODS: Retrospective evaluation of datasets from the national Clinical Practice Research Datalink (CPRD) and from a single large regional centre. Data were extracted for cohorts of consecutive adults aged over 40 years for whom a CXR had been performed between 2016 and 2018. Using cancer registry data, the incidence of lung cancer within a 2 years of the CXR referral and the variations with age, gender, and smoking status were evaluated. RESULTS: A total of 291 294 CXR events were evaluated from the combined datasets. The incidence of lung cancer amongst primary care CXR referrals was 1.4% in CPRD with a consistent correlation with increasing age and smoking status. The incidence of lung cancer within two-years of the CXR varied between 0.03% (95%CI, 0.0-0.1) amongst never smokers aged 40-45 years to 4.8% (95%CI, 4.2-5.5) amongst current-smokers aged 70-75 years. The findings were similar for the single large centre data, although cancer incidence was higher. CONCLUSIONS: A simple estimation and stratification of the risk of lung cancer amongst primary care referrals for investigation with a CXR is possible using age and smoking status. ADVANCES IN KNOWLEDGE: This is the first estimate of the incidence of lung cancer amongst primary care CXR referrals and a demonstration of how the demographic information contained within a request could be used to optimize investigations and interpret test results. |
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| 投稿者 | Bhartia, Bobby S K; Baldwin, David; Bradley, Stephen H; Callister, Matthew E J; Das, Indrajeet; Evison, Matthew; Grundy, Seamus; Kaur, Jaspreet; Kennedy, Martyn; O'Dowd, Emma L |
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| 組織名 | Department of Clinical Radiology, Leeds Teaching Hospitals NHS Trust, Leeds, LS9;7TF, United Kingdom.;Respiratory Medicine, Nottingham University Hospitals NHS Trust, University of;Nottingham, NG5 1PB, United Kingdom.;School of Medicine, University of Leeds, Leeds LS2 9JT, United Kingdom.;Department of Respiratory Medicine, Leeds Teaching Hospitals NHS Trust, Leeds,;LS9 7TF, United Kingdom.;Department of Clinical Radiology, University Hospitals of Leicester NHS trust,;Leicester, LE1 5WW, United Kingdom.;Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, M23;9LT, United Kingdom.;Department of Respiratory Medicine, Salford Royal Hospital, Northern Care;Alliance NHS Foundation Trust, Salford, M6 8HD, United Kingdom.;University of Nottingham, Nottingham, Nottingham, NG7 2RD, United Kingdom. |
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