| アブストラクト | OBJECTIVES: To determine the incidence of lung cancer amongst primary care referrals for investigation with a chest radiograph (CXR). METHOD: Retrospective evaluation of datasets from the national Clinical Practice Research Datalink (CPRD) and from a single large regional centre. Data was extracted for cohorts of consecutive adults aged over 40-yrs for whom a CXR had been performed between 2016 and 2018. Using cancer registry data, the incidence of lung cancer within a two-years of the CXR referral and the variations with age, gender and smoking status were evaluated. RESULTS: A total of 291 294 CXR events were evaluated from the combined datasets. The incidence of lung cancer amongst GP CXR referrals was 1.4% in CPRD with a consistent correlation with increasing age and smoking status. The incidence of lung cancer within two-years of the CXR varied between 0.03% (95%CI 0.0-0.1) amongst never smokers aged 40-45 years to 4.8% (95%CI 4.2-5.5) amongst current-smokers aged 70-75 years. The findings were similar for the single large centre data, although cancer incidence was higher. CONCLUSIONS: A simple estimation and stratification of the risk of lung cancer amongst primary care referrals for investigation with a CXR is possible using age and smoking status. ADVANCES IN KNOWLEDGE: This is the first estimate of the incidence of lung cancer amongst primary care CXR referrals and a demonstration of how the demographic information contained within a request could be used to optimise investigations and interpret test results. |
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| ジャーナル名 | The British journal of radiology |
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| 投稿日 | 2024/8/20 |
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| 投稿者 | Bhartia, Bobby S K; Baldwin, David; Bradley, Stephen H; Callister, Matthew E J; Das, Indrajeet; Evison, Matthew; Grundy, Seamus; Kaur, Jaspreet; Kennedy, Martyn; O'Dowd, Emma L |
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| 組織名 | Department of Clinical Radiology, Leeds Teaching Hospitals NHS Trust.;Respiratory Medicine, Nottingham University Hospitals NHS Trust and University of;Nottingham.;NIHR Academic Clinical Lecturer, University of Leeds.;Department of Respiratory Medicine, Leeds Teaching Hospitals NHS Trust.;Department of Clinical Radiology, University Hospitals of Leicester NHS trust.;Lung Cancer & Thoracic Surgery Directorate, Wythenshawe Hospital, Manchester;University NHS Foundation Trust.;Department of Respiratory Medicine, Salford Royal Hospital, Northern Care;Alliance NHS Foundation Trust.;University of Nottingham, Nottingham, UK. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/39163502/ |
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