| アブストラクト | BACKGROUND: Depression is known to be associated with a greater risk of developing cardiovascular disease (CVD) in middle-aged people. However, it is not certain how depression would influence incident CVD in older people aged >/= 75 years. We investigated the association between depression and CVD in older people. METHODS: We analyzed 146,085 individuals aged >/= 75 years including 7581 individuals (5.2%) with depression registered in the DeSC database from April 2014 to November 2022. We excluded those with a prior history of CVD. The incidence of composite CVD events, comprising ischemic heart disease (IHD), heart failure, and stroke was documented. A Cox proportional hazard regression analysis was conducted to estimate hazard ratios (HR) associated with the presence of depression. RESULTS: The median age was 79 years and 41.0% were men. During the mean follow-up period of 3.4 +/- 1.5 years, 39,552 composite CVD events (IHD: n = 10,916; heart failure: n = 26,719; stroke: n = 13,090) were recorded. Multivariable Cox regression analyses showed that older individuals with depression had a greater risk of composite CVD events than those without (hazard ratio [HR] 1.29, 95% confidence interval [CI] 1.24-1.34). The HR (95% CI) of depression was 1.26 (1.17-1.37) for IHD, 1.25 (1.19-1.31) for heart failure, and 1.30 (1.21-1.39) for stroke, respectively. While considering the limitations of real-world data, we conducted multiple sensitivity analyses, which confirmed the results of the primary analysis. CONCLUSIONS: The presence of depression was independently associated with a greater risk of developing CVD even in older individuals. |
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| ジャーナル名 | European geriatric medicine |
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| Pubmed追加日 | 2025/2/1 |
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| 投稿者 | Komuro, Kaoruko; Komuro, Jin; Kaneko, Hidehiro; Suzuki, Yuta; Okada, Akira; Fujiu, Katsuhito; Takeda, Norifumi; Morita, Hiroyuki; Node, Koichi; Yasunaga, Hideo; Komuro, Issei; Ieda, Masaki; Takeda, Norihiko |
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| 組織名 | Department of Cardiology, Keio University School of Medicine, Tokyo, Japan.;Department of Cardiovascular Medicine, The University of Tokyo, 7-3-1, Hongo,;Bunkyo-ku, Tokyo, 113-8655, Japan.;Bunkyo-ku, Tokyo, 113-8655, Japan. kanekohidehiro@gmail.com.;Department of Advanced Cardiology, The University of Tokyo, Tokyo, Japan.;kanekohidehiro@gmail.com.;Center for Outcomes Research and Economic Evaluation for Health, National;Institute of Public Health, Saitama, Japan.;Department of Prevention of Diabetes and Lifestyle-Related Diseases, Graduate;School of Medicine, The University of Tokyo, Tokyo, Japan.;Department of Cardiovascular Medicine, Saga University, Saga, Japan.;Department of Clinical Epidemiology and Health Economics, School of Public;Health, The University of Tokyo, Tokyo, Japan.;International University of Health and Welfare, Tokyo, Japan.;Department of Frontier Cardiovascular Science, Graduate School of Medicine, The;University of Tokyo, Tokyo, Japan. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/39891821/ |
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