| アブストラクト | Antibiotic-associated acute kidney injury (AA-AKI) is quite common, especially among hospitalized patients; however, little is known about risk factors or mechanisms of why AA-AKI occurs. In this review, the authors have reviewed all available literature prior to 1 June 2022, with a large number of AKI reports. Information regarding risk factors of AA-AKI, mechanisms behind AA-AKI, and treatment/management principles to decrease AA-AKI risk were collected and reviewed. Patients treated in the inpatient setting are at increased risk of AA-AKI due to common risk factors: hypovolemia, concomitant use of other nephrotoxic medications, and exacerbation of comorbid conditions. Clinicians should attempt to correct risk factors for AA-AKI, choose antibiotic therapies with decreased association of AA-AKI to protect their high-risk patients, and narrow, when clinically possible, the use of antibiotics which have decreased incidence of AKI. To treat AKI, it is still recommended to discontinue all offending nephrotoxic agents and to renally adjust all medications according to package insert recommendations to decrease patient harm. |
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| ジャーナル名 | Antibiotics (Basel, Switzerland) |
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| 投稿日 | 2022/10/28 |
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| 投稿者 | Clifford, Kalin M; Selby, Ashley R; Reveles, Kelly R; Teng, Chengwen; Hall, Ronald G 2nd; McCarrell, Jamie; Alvarez, Carlos A |
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| 組織名 | Department of Pharmacy Practice, Jerry H. Hodge School of Pharmacy, Texas Tech;University Health Sciences Center, Dallas, TX 75235, USA.;College of Pharmacy, The University of Texas at Austin, Austin, TX 78701, USA.;Pharmacotherapy Education and Research Center, University of Texas Health San;Antonio, San Antonio, TX 78229, USA.;Department of Clinical Pharmacy and Outcomes Sciences, College of Pharmacy,;University of South Carolina, Columbia, SC 29208, USA.;Department of Pharmacy, Baptist St. Anthony's Health System, Amarillo, TX 79106,;USA. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/36290024/ |
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