| アブストラクト | BACKGROUND: Colorectal cancer survival has improved in recent decades but there are concerns that survivors may develop kidney problems due to adverse effects of cancer treatment or complications of the cancer itself. We quantified the risk of acute kidney injury (AKI) in colorectal cancer survivors compared to people with no prior cancer. METHODS: Retrospective matched cohort study using electronic health record primary care data from the Clinical Practice Research Datalink GOLD linked to hospital data in England (HES-APC). Individuals with colorectal cancer between 1997-2018 were individually matched on age, sex, and GP practice to people with no prior cancer. We used Cox models to estimate hazard ratios for an incident hospital diagnosis of AKI in colorectal cancer survivors compared to individuals without cancer, overall and stratified by time since diagnosis adjusted for other individual-level factors (adj-HR). RESULTS: Twenty thousand three hundred forty colorectal cancer survivors were matched to 100,058 cancer-free individuals. Colorectal cancer survivors were at increased risk of developing AKI compared to people without cancer (adj-HR = 2.16; 95%CI 2.05-2.27). The HR was highest in the year after diagnosis (adj-HR 7.47, 6.66-8.37), and attenuated over time, but there was still increased AKI risk > 5 years after diagnosis (adj-HR = 1.26, 1.17-1.37). The association between colorectal cancer and AKI was greater for younger people, men, and those with pre-existing chronic kidney disease. CONCLUSIONS: Colorectal cancer survivors were at increased risk of AKI for several years after cancer diagnosis, suggesting a need to prioritise monitoring, prevention, and management of kidney problems in this group of cancer survivors. |
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| ジャーナル名 | BMC cancer |
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| 投稿日 | 2023/9/8 |
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| 投稿者 | Andresen, Kirsty; Carreira, Helena; Strongman, Helen; McDonald, Helen I; Benitez-Majano, Sara; Mansfield, Kathryn E; Nitsch, Dorothea; Tomlinson, Laurie A; Bhaskaran, Krishnan |
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| 組織名 | Department of Non-Communicable Disease Epidemiology, Faculty of Epidemiology and;Population Health, London School of Hygiene & Tropical Medicine, Keppel Street,;London, WC1E 7HT, UK.;Department of Infectious Disease Epidemiology, Faculty of Epidemiology and;London, WC1E 7HT, UK. Krishnan.bhaskaran@lshtm.ac.uk. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/37679679/ |
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