| アブストラクト | OBJECTIVE: To determine the risk of mortality in patients with psoriasis. DESIGN: Cohort study. SETTING: General practitioners participating in the General Practice Research Database in the United Kingdom, 1987-2002. PATIENTS: Mild psoriasis, defined as any patient with a diagnostic code of psoriasis but no history of systemic therapy; severe psoriasis, any patient with a diagnostic code of psoriasis and a history of systemic therapy consistent with severe psoriasis. The unexposed (control) population was composed of patients with no history of a psoriasis diagnostic code. Control patients were selected in a 5:1 ratio from the same practice and date in practice as the patients with psoriasis. MAIN OUTCOME MEASURE: Hazard ratio (HR) of time to death using Cox proportional hazards models adjusted for age and sex. RESULTS: There was no overall effect of mild psoriasis on mortality (HR, 1.0; 95% confidence interval [CI], 0.97-1.02), whereas patients with severe psoriasis demonstrated an increased overall mortality risk (HR, 1.5; 95% CI, 1.3-1.7). The association of severe psoriasis with mortality persisted after adjustment for risk factors for mortality (HR, 1.4; 95% CI, 1.3-1.6) and after exclusion of patients with inflammatory arthropathy (HR, 1.5; 95% CI, 1.3-1.8). Male and female patients with severe psoriasis died 3.5 (95% CI, 1.2-5.8) and 4.4 (95% CI, 2.2-6.6) years younger, respectively, than patients without psoriasis (P < .001). CONCLUSION: Severe but not mild psoriasis is associated with an increased risk of death. |
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| ジャーナル名 | Archives of dermatology |
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| Pubmed追加日 | 2007/12/19 |
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| 投稿者 | Gelfand, Joel M; Troxel, Andrea B; Lewis, James D; Kurd, Shanu Kohli; Shin, Daniel B; Wang, Xingmei; Margolis, David J; Strom, Brian L |
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| 組織名 | MSCE, Department of Dermatology, University of Pennsylvania School of Medicine, 2;Maloney Bldg, 3600 Spruce St, Philadelphia, PA 19104, USA.;Joel.Gelfand@uphs.upenn.edu |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/18086997/ |
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