| アブストラクト | Investigators postulated that early-life exposure to organic mercury (Hg) significantly increases the risk of childhood neurodevelopmental disorders (NDs). The Vaccine Adverse Event Reporting System database was utilized to conduct a hypothesis testing case-control study by evaluating 3486 total adverse event reports reported following Haemophilus influenza type b (Hib) vaccination. Exposed subjects received a Thimerosal-containing formulation (HIBTITER, Wyeth-Lederle), while unexposed subjects received a Thimerosal-free formulation (PEDVAXHIB, Merck). Subjects were included if they received either of these two Hib vaccine formulations between 1995 and 1999. Cases were defined as adverse event reports with a reported outcome of autism, developmental delay, psychomotor delay, or NDs in general. Cases with reported outcomes of febrile convulsions, pyrexia, or injection site pain, all of which have no biologically plausible relation to Hg exposure, were also examined. Controls were defined as adverse event reports without any mention of the specific case outcome examined. Cases of reported autism (odds ratio (OR)=2.75, p<0.02), developmental delay (OR=5.39, p<0.01), psychomotor disorder (OR=2.38, p<0.03), and neurodevelopmental disorder in general (OR=2.70, p<0.001) were each significantly more likely than their respective controls to receive Thimerosal-containing Hib vaccine than Thimerosal-free Hib vaccine. Significant effects for neurodevelopmental disorder in general were observed for males (OR=2.52, p<0.005), but not females when separated by gender. For the outcomes that had no biologically plausible relation to Hg exposure, the cases were no more likely than their respective controls to receive Thimerosal-containing Hib vaccine than Thimerosal-free Hib vaccine. This study provides suggestive evidence of an association between Thimerosal and neurodevelopmental outcomes and provides support for carrying out additional well-designed studies examining the association between Thimerosal-containing vaccines and a wide range of neurodevelopmental outcomes. |
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| 投稿日 | 2018/3/27 |
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| 投稿者 | Geier, David A; Kern, Janet K; Homme, Kristin G; Geier, Mark R |
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| ジャーナル名 | International journal of hygiene and environmental health |
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| 組織名 | The Institute of Chronic Illnesses, Inc, Silver Spring, MD, USA; CoMeD, Inc,;Silver Spring, MD, USA.;Silver Spring, MD, USA; CONEM US Autism Research Group, Allen, TX, USA.;Electronic address: jkern@dfwair.net.;International Academy of Oral Medicine and Toxicology, Champions Gate, FL, USA.;The Institute of Chronic Illnesses, Inc, Silver Spring, MD, USA. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/29573974/ |
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