| アブストラクト | OBJECTIVE: The objective of this case/non-case study was to detect rebamipide-related pulmonary adverse events (AE) compared with other drugs for acid-related disorders based on population-level data. METHODS: From 2009 to 2018, AE reports on drugs for acid-related disorders, which are anatomical therapeutic chemical code A02B drugs, in the Korea Adverse Events Reporting System (KAERS) database were examined. The reporting odds ratio (ROR) was calculated, and the odds of reporting pulmonary AE for rebamipide and all other A02B drugs were compared. Furthermore, a stratified analysis according to patients' age and sex was conducted. RESULTS: Altogether 13 (0.05%) and 157 (0.11%) cases of pulmonary AE were reported for rebamipide and all other A02B drugs, respectively. The risk of reporting pulmonary AE was significantly lower for rebamipide than for all other A02B drugs (ROR 0.49, 95% confidence interval [CI] 0.28-0.87). The number of reports of pulmonary AE for rebamipide was significantly higher among patients aged >/=65 years than those aged <65 years (ROR 19.36, 95% CI 2.50-149.97). CONCLUSIONS: Rebamipide was less often reported for pulmonary AE. However, healthcare professionals need to be aware of the risk of pulmonary AE in elderly patients. |
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| ジャーナル名 | Journal of digestive diseases |
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| 投稿日 | 2021/12/30 |
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| 投稿者 | Yang, Bo Ram; Lee, Jae-Young; Kim, Myeong Gyu |
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| 組織名 | College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea.;College of Pharmacy, Ewha Womans University, Seoul, Republic of Korea.;Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul,;Republic of Korea. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/34965009/ |
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