| アブストラクト | Vaccination against COVID-19 is the cornerstone of controlling and mitigating the ongoing pandemic. Thrombotic adverse events linked to Moderna, Pfizer and the Oxford-AstraZeneca vaccine have been documented and described as extremely rare. While the Oxford-AstraZeneca vaccine has received much of the attention, the other vaccines should not go unchallenged. This study aimed to determine the frequency of reported thrombotic adverse events and clinical outcomes for these three COVID-19 vaccines, namely, Moderna, Pfizer and Oxford-AstraZeneca. A retrospective descriptive analysis was conducted of spontaneous reports for Moderna, Pfizer and Oxford-AstraZeneca COVID-19 vaccines submitted to the EudraVigilance database in the period from 17 February to 14 June 2021. There were 729,496 adverse events for the three vaccines, of which 3420 were thrombotic, mainly Oxford-AstraZeneca (n = 1988; 58.1%) followed by Pfizer (n = 1096; 32.0%) and Moderna (n = 336; 9.8%). As serious adverse events, there were 705 reports of pulmonary embolism for the three vaccines, of which 130 reports (18.4%) were for Moderna, 226 reports (32.1%) for Pfizer and 349 (49.5%) for Oxford-AstraZeneca vaccines. The occurrence of pulmonary embolism is significantly associated with a fatal outcome (p </= 0.001). Sixty-three fatalities were recorded (n = 63/3420; 1.8%), of which Moderna (n = 6), Pfizer (n = 25) and Oxford-AstraZeneca (n = 32). |
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| ジャーナル名 | Vaccines |
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| 投稿日 | 2021/11/28 |
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| 投稿者 | Tobaiqy, Mansour; MacLure, Katie; Elkout, Hajer; Stewart, Derek |
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| 組織名 | Department of Pharmacology, College of Medicine, University of Jeddah, Jeddah;P.O. Box 45311, Saudi Arabia.;Independent Researcher, Aberdeen AB32 6RU, UK.;Department of Family and Community Medicine, Medical Faculty, University of;Tripoli, Tripoli P.O. Box 13662, Libya.;College of Pharmacy, QU Health, Qatar University, Doha P.O. Box 2713, Qatar. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/34835256/ |
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