| アブストラクト | BACKGROUND: Tracheostomy is often performed in patients with severe burns who are undergoing prolonged mechanical ventilation. However, the appropriate timing of tracheostomy and its effect on mortality remain unknown. The aim of this study was to determine whether tracheostomy can reduce mortality in patients with severe burns. METHODS: Using the Japanese Diagnosis Procedure Combination database from April 2010 to March 2014, we extracted data on adult patients with severe burns (burn index score of >/=15) who started mechanical ventilation within 3days of admission. We estimated the hazard ratio for 28-day in-hospital mortality associated with tracheotomy performed from day 5 to 28. We adjusted for baseline and time-dependent confounders using inverse probability of treatment weighting methods and fitted a marginal structural Cox proportional hazard model. RESULTS: We identified 680 eligible patients (94 in the tracheostomy group, 2289 person-days; 586 in the non-tracheostomy group, 11,197 person-days). Patients who underwent a tracheostomy had worse prognostic factors for mortality. After adjustment for these factors, the hazard ratio for 28-day mortality associated with tracheostomy compared with non-tracheostomy was 0.73 (95% confidence interval, 0.39-1.34). CONCLUSIONS: There was no significant association between 28-day in-hospital mortality and early tracheostomy in adult patients with severe burns. |
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| 投稿者 | Tsuchiya, Asuka; Yamana, Hayato; Kawahara, Takuya; Tsutsumi, Yusuke; Matsui, Hiroki; Fushimi, Kiyohide; Yasunaga, Hideo |
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| 組織名 | Department of Clinical Epidemiology & Health Economics, School of Public Health,;The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan;;Department of Emergency and Critical Care Medicine, National Hospital;Organization Mito Medical Center 280 Sakuranosato, Ibarakimachi,;Higahi-Ibaraki-gun, Ibaraki 311-3193, Japan. Electronic address:;asuka-t@umin.ac.jp.;The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.;Electronic address: yamana-tky@umin.ac.jp.;Biostatistics Division, Central Coordinating Unit, Clinical Research Support;Center, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655,;Japan. Electronic address: tkawahara-tky@umin.ac.jp.;tsutsumi.yusuke.84x@st.kyoto-u.ac.jp.;Electronic address: ptmatsui-tky@umin.ac.jp.;Department of Health Policy and Informatics, Tokyo Medical and Dental University,;1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan. Electronic address:;kfushimi.hci@tmd.ac.jp.;Electronic address: yasunagah-tky@umin.ac.jp. |
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