| アブストラクト | BACKGROUND: People with multiple sclerosis (PwMS) have an increased cardiovascular and cerebrovascular disease burden, but this could be mitigated by vascular risk factor management. OBJECTIVES: We compared the trajectories of vascular risk factors, vascular comorbidities and clinical management in PwMS against the general population post-MS diagnosis while controlling for frailty. METHODS: Retrospective longitudinal analysis using English data from the Clinical Practice Research Datalink between 1987 and 2018 comprising PwMS matched with up to six controls without MS by age, sex and general practice. RESULTS: We compared 12,251 PwMS with 72,572 matched controls; 3.8% of PwMS had mild-moderate frailty, 1.2% more than matched controls. Compared to controls, PwMS had an elevated incidence of Type 2 diabetes (HR 1.18, 95% CI (1.04, 1.34)), and starting antihypertensive medications (HR 1.40, 95% CI (1.33, 1.47)). Among those with hypertension at baseline, blood pressure trajectories did not differ between PwMS and controls. PwMS had increased rates of meeting targets for hypertension management (HR 1.25, 95% CI (1.12, 1.41)). CONCLUSION: The observation that PwMS with hypertension are more likely to meet treatment targets than matched controls is encouraging, but the elevated rates of vascular comorbidities suggest that tighter vascular management may be needed in this population. |
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| ジャーナル名 | Multiple sclerosis (Houndmills, Basingstoke, England) |
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| 投稿日 | 2024/10/18 |
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| 投稿者 | Palladino, Raffaele; Chataway, Jeremy; Mathew, Mekha; Majeed, Azeem; Marrie, Ruth Ann |
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| 組織名 | Department of Primary Care and Public Health, School of Public Health, Imperial;College London, London, UK.;Department of Public Health, University of Naples Federico II, Naples, Italy.;Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL;Queen Square Institute of Neurology, Faculty of Brain Sciences, University;University College London Hospitals Biomedical Research Centre, National;Institute for Health Research, London, UK.;Departments of Medicine and Community Health Sciences, Max Rady College of;Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB,;Canada. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/39420581/ |
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