| アブストラクト | OBJECTIVE: To describe the features of transient bulging fontanelle (TBF) after vaccination. STUDY DESIGN: We searched the Vaccine Adverse Event Reporting System database for reports describing bulging fontanelle. We defined a definite TBF case as a patient with a bulging fontanelle, normal neuroimaging and cerebrospinal fluid analysis, and absence of a depressed level of consciousness, focal neurologic findings, or identified cause. Follow-up had to reveal normal development. Probable cases lacked either lumbar puncture or neuroimaging or both but met all other criteria. RESULTS: We identified 18 patients with definite or probable TBF. The median age at presentation was 4.5 months, interval from vaccination to symptom onset was 18 hours, and time to resolution was 3 days. Fifteen children were febrile. CONCLUSIONS: We cannot conclude that vaccines cause TBF. Further controlled studies are necessary. Even if further research verifies TBF as a rare side effect, immunization benefits would still vastly outweigh this hypothetical risk. However, confirmation of a vaccine association could modify the management of infants who develop TBF after immunizations. |
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| ジャーナル名 | The Journal of pediatrics |
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| 投稿日 | 2005/11/18 |
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| 投稿者 | Freedman, Stephen B; Reed, John; Burwen, Dale R; Wise, Robert P; Weiss, Amy; Ball, Robert |
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| 組織名 | Division of Pediatric Emergency Medicine, Department of Pediatrics, The Hospital;for Sick Children, University of Toronto, Toronto, Ontario, Canada. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/16291356/ |
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