| アブストラクト | BACKGROUND: Uncomplicated urinary tract infections (uUTIs) are common bacterial infections. AIM: To evaluate the burden of uUTI in England for 1) potential determinants of disease progression; 2) extent and impact of antimicrobial prescribing non-concordant with treatment guidelines; and 3) healthcare burden and economic costs. DESIGN & SETTING: Retrospective cohort study utilising patient data (January 2017-February 2020) from the Clinical Practice Research Datalink (CPRD) linked to English Hospital Episode Statistics. METHOD: Female patients aged >/=12 years with a new uUTI between 2018 and 2019, >/=14 months' continuous CPRD enrolment (>/=12 months baseline, >/=2 months follow-up), and >/=1 oral antibiotic prescription +/-5 days of uUTI diagnosis were included. Baseline characteristics were described in patients with or without disease progression (hospitalisation for acute pyelonephritis, bacteraemia, or sepsis). Treatment non-concordance with current English guidelines was assessed. Burden (all-cause and urinary tract infection-related healthcare resource use [HCRU] and costs) was evaluated in a 1:1 age and comorbidity-matched uUTI-free cohort. RESULTS: Of 120 519 patients, 207 (0.2%) had disease progression requiring hospitalisation (during index uUTI episode); determinants included older age, index uUTI home consultation, prior hospitalisation, and medications prescribed for comorbid conditions in the prior 12 months (British National Formulary classes: cardiovascular system, eye, and other drugs and preparations). Non-concordant treatment was observed in 43.5% of patients. All-cause HCRU burden and costs were significantly higher in patients with uUTI versus age and comorbidity-matched controls (P<0.001) at 28 days ( pound160.06 versus pound37.63) and in the 12-month follow-up ( pound1206.77 versus pound460.97). CONCLUSION: All-cause HCRU burden and costs were significantly higher in patients with uUTI versus matched controls (P<0.001). Hospitalisation for acute pyelonephritis, bacteraemia, or sepsis following uUTI was uncommon. |
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| ジャーナル名 | BJGP open |
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| Pubmed追加日 | 2024/12/13 |
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| 投稿者 | Wilcox, Mark H; Heaton, Dave; Mulgirigama, Aruni; Joshi, Ashish V; Chirikov, Viktor; Gibbons, Daniel C; Webb, David; Marston, Xiaocong L; Alexander, Myriam Na; Mitrani-Gold, Fanny S |
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| 組織名 | Department of Microbiology, University of Leeds, Leeds, UK.;Leeds Teaching Hospitals NHS Trust, Leeds, UK.;OPEN Health, Marlow, UK.;GSK, London, UK.;GSK, Collegeville, PA, US.;OPEN Health, Bethesda, MD, US.;GSK, Collegeville, PA, US fanny.s.mitrani-gold@gsk.com. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/39667795/ |
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