| アブストラクト | OBJECTIVE: To investigate the incidence of cardiovascular disease (CVD) overall and by age, sex, and socioeconomic status, and its variation over time, in the UK during 2000-19. DESIGN: Population based study. SETTING: UK. PARTICIPANTS: 1 650 052 individuals registered with a general practice contributing to Clinical Practice Research Datalink and newly diagnosed with at least one CVD from 1 January 2000 to 30 June 2019. MAIN OUTCOME MEASURES: The primary outcome was incident diagnosis of CVD, comprising acute coronary syndrome, aortic aneurysm, aortic stenosis, atrial fibrillation or flutter, chronic ischaemic heart disease, heart failure, peripheral artery disease, second or third degree heart block, stroke (ischaemic, haemorrhagic, and unspecified), and venous thromboembolism (deep vein thrombosis or pulmonary embolism). Disease incidence rates were calculated individually and as a composite outcome of all 10 CVDs combined and were standardised for age and sex using the 2013 European standard population. Negative binomial regression models investigated temporal trends and variation by age, sex, and socioeconomic status. RESULTS: The mean age of the population was 70.5 years and 47.6% (n=784 904) were women. The age and sex standardised incidence of all 10 prespecified CVDs declined by 19% during 2000-19 (incidence rate ratio 2017-19 v 2000-02: 0.80, 95% confidence interval 0.73 to 0.88). The incidence of coronary heart disease and stroke decreased by about 30% (incidence rate ratios for acute coronary syndrome, chronic ischaemic heart disease, and stroke were 0.70 (0.69 to 0.70), 0.67 (0.66 to 0.67), and 0.75 (0.67 to 0.83), respectively). In parallel, an increasing number of diagnoses of cardiac arrhythmias, valve disease, and thromboembolic diseases were observed. As a result, the overall incidence of CVDs across the 10 conditions remained relatively stable from the mid-2000s. Age stratified analyses further showed that the observed decline in coronary heart disease incidence was largely restricted to age groups older than 60 years, with little or no improvement in younger age groups. Trends were generally similar between men and women. A socioeconomic gradient was observed for almost every CVD investigated. The gradient did not decrease over time and was most noticeable for peripheral artery disease (incidence rate ratio most deprived v least deprived: 1.98 (1.87 to 2.09)), acute coronary syndrome (1.55 (1.54 to 1.57)), and heart failure (1.50 (1.41 to 1.59)). CONCLUSIONS: Despite substantial improvements in the prevention of atherosclerotic diseases in the UK, the overall burden of CVDs remained high during 2000-19. For CVDs to decrease further, future prevention strategies might need to consider a broader spectrum of conditions, including arrhythmias, valve diseases, and thromboembolism, and examine the specific needs of younger age groups and socioeconomically deprived populations. |
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| ジャーナル名 | BMJ (Clinical research ed.) |
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| 投稿日 | 2024/6/27 |
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| 投稿者 | Conrad, Nathalie; Molenberghs, Geert; Verbeke, Geert; Zaccardi, Francesco; Lawson, Claire; Friday, Jocelyn M; Su, Huimin; Jhund, Pardeep S; Sattar, Naveed; Rahimi, Kazem; Cleland, John G; Khunti, Kamlesh; Budts, Werner; McMurray, John J V |
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| 組織名 | School of Cardiovascular and Metabolic Health, British Heart Foundation;Cardiovascular Research Centre, University of Glasgow, Glasgow, UK;nathalie.conrad@kuleuven.be.;Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium.;Deep Medicine, Nuffield Department of Women's and Reproductive Health, University;of Oxford, Oxford, UK.;Interuniversity Institute for Biostatistics and statistical Bioinformatics;(I-BioStat), Hasselt University and KU Leuven, Belgium.;Leicester Real World Evidence Unit, Diabetes Research Centre, University of;Leicester, Leicester, UK.;Cardiovascular Research Centre, University of Glasgow, Glasgow, UK.;College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow,;UK.;Congenital and Structural Cardiology, University Hospitals Leuven, Belgium. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/38925788/ |
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