| アブストラクト | BACKGROUND AND AIMS: Assessment of mortality trends and real-world outcomes are important for monitoring acute myocardial infarction (AMI) care, although there is limited data beyond 1-year post incident AMI. METHODS: We used Clinical Practice Research Datalink Aurum to identify patients >/= 35 with incident AMI between 1 Jan 2006 to 31 Dec 2014. Data was also extracted from three other sources. Risk of all-cause and cardiovascular (CV)-related mortality, incident heart failure (HF), recurrent AMI, and cerebrovascular accidents (CVA) were calculated at 1- and 5-years using regression analysis-2006 was the comparator. RESULTS: We identified 94,241 patients with AMI. The 1-year risk for multiple outcomes fell by 2014, including all-cause mortality (hazard ratio (HR): 0.82, 95% CI: 0.75-0.90), CV-related mortality (HR: 0.69, 95% CI: 0.60-0.78), and recurrent AMI (HR 0.72, 95% CI: 0.66-0.79). The 1-year risk for incident HF increased (HR: 1.18, 95% CI: 1.08-1.28) whilst CVA risk did not change (HR: 1.11, 95% CI: 0.98-1.26). At 5-years, the risk fell for all-cause mortality (HR: 0.82, 95% CI: 0.79-0.87), CV-related mortality (HR: 0.68, 95% CI: 0.62-0.74), and recurrent AMI (HR: 0.71, 95% CI: 0.65-0.75) by 2014. The 5-year risk for incident HF increased (HR: 1.15, 95% CI: 1.08-1.23), whilst CVA risk also increased significantly (HR: 1.16, 95% CI: 1.07-1.26) by 2014. CONCLUSIONS: Across 2006-2014, we observed a falling risk of all-cause mortality, CV-related mortality, and recurrent AMI at 1- and 5-years post incident AMI. Countervailing trends were seen for incident HF, where the risk for CVA also increased significantly by 5-years. |
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| ジャーナル名 | BMC cardiovascular disorders |
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| Pubmed追加日 | 2026/1/10 |
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| 投稿者 | Scholfield, Steven; Zghebi, Salwa S; Rutter, Martin; Mamas, Mamas A; Kontopantelis, Evangelos |
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| 組織名 | Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of;Biology, Medicine and Health, University of Manchester, Manchester, UK.;steven.scholfield@postgrad.manchester.ac.uk.;Division of Population Health, Health Services Research and Primary Care, School;of Health Sciences, Faculty of Biology, Medicine and Health, University of;Manchester, Manchester, UK.;Division of Diabetes, Endocrinology & Gastroenterology, School of Medical;Sciences, Faculty of Biology, Medicine and Health, University of Manchester,;Manchester, UK.;Keele Cardiovascular Research Group, Centre for Prognosis Research, Institute for;Primary Care and Health Sciences, Keele University, Keele, UK.;Division of Informatics, Imaging and Data Sciences, School of Health Sciences,;Faculty of Biology, Medicine and Health, University of Manchester, Manchester,;UK. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/41514213/ |
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