| アブストラクト | Aim: Comprehensively characterize the cardiotoxicity of CD19-directed chimeric antigen receptor T-cell (CAR-T) products. Materials & methods: Data between 2017 and 2021 in the US FDA's Adverse Event Reporting System database were utilized. Disproportionality was measured using reporting odds ratio and information component. Hierarchical clustering analysis was performed to explore the relationships among cardiac events. Results: Tisagenlecleucel exhibited the highest percentage of death (53.24%) and life-threatening (13.39%) outcomes. Axicabtagene ciloleucel and tisagenlecleucel were equal in the number of positive signals (n = 15), while the former had excessive reporting of several cardiac events versus the latter, such as atrial fibrillation, cardiomyopathy, cardiorenal syndrome and sinus bradycardia. Conclusion: Several cardiac risks should be considered for CAR-T treatment and these events might vary in frequency and severity following different CAR-T agents. |
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| ジャーナル名 | Immunotherapy |
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| 投稿日 | 2023/3/24 |
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| 投稿者 | Zhai, Yinghong; Hu, Fangyuan; Zhu, Borui; Xu, Jinfang; Guo, Xiaojing; Shi, Wentao; Zhou, Xiang; Zheng, Yi; Xu, Xiao; Ye, Xiaofei; He, Jia; Xu, Feng |
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| 組織名 | Clinical Research Center, School of Medicine, Shanghai Ninth People's Hospital;Affiliated to Shanghai Jiao Tong University, Shanghai, 200011, China.;Department of Medical Service, Naval Hospital of Eastern theater, Zhejiang;Zhoushan, 316000, China.;Department of Health Statistics, Second Military Medical University, Shanghai,;200433, China.;Tongji University School of Medicine, 1239 Siping Road, Yangpu District,;Shanghai, 200092, China. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/36951157/ |
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