| アブストラクト | BACKGROUND: Although the relation between statin use and liver cancer risk has been extensively examined, few studies have examined other cholesterol-lowering medications in relation to liver cancer risk. The authors examined five classes of nonstatin medications and liver cancer risk. METHODS: A nested case-control including 3719 cases and 14,876 matched controls was conducted within the Clinical Practice Research Datalink. Additional matches on type 2 diabetes and chronic liver disease were also implemented. The medications examined included cholesterol absorption inhibitors, bile acid sequestrants, fibrates, niacin, and omega-3 fatty acids. Conditional logistic regression estimated odds ratios and 95% confidence intervals. RESULTS: Cholesterol absorption inhibitor use was associated with reduced liver cancer risk in the overall analysis (odds ratio, 0.69; 95% confidence interval, 0.50-0.96) and in analyses based on type 2 diabetes and chronic liver disease status. Although bile acid sequestrant use was associated with increased liver cancer risk in the overall analysis (odds ratio, 5.31; 95% confidence interval, 3.53-7.97), the results of the analyses based on type 2 diabetes and chronic liver disease status were inconsistent. [Correction added on 19 August 2024, after first online publication: In the preceding sentence, the value '3.534' has been changed to '3.54'.]. No associations were observed for the other medications. CONCLUSIONS: Cholesterol absorption inhibitors may be associated with reduced liver cancer risk. Whether bile acid sequestrant use was associated with increased risk was only partially supported in the current study. |
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| ジャーナル名 | Cancer |
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| Pubmed追加日 | 2024/7/29 |
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| 投稿者 | Zamani, Shahriar A; Graubard, Barry I; Hyer, Marianne; Carver, Emily; Petrick, Jessica L; McGlynn, Katherine A |
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| 組織名 | Division of Cancer Epidemiology and Genetics, National Cancer Institute, National;Institutes of Health, Rockville, Maryland, USA.;Cancer Prevention Fellowship Program, Division of Cancer Prevention, National;Cancer Institute, National Institutes of Health, Rockville, Maryland, USA.;Information Management Services, Rockville, Maryland, USA.;Slone Epidemiology Center, Boston University, Boston, Massachusetts, USA. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/39072717/ |
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