| アブストラクト | BACKGROUND: Use of oral glucocorticoids (GCs) has been associated with hyperglycaemia and type 2 diabetes mellitus (T2DM). However, unlike oral GCs, there is minimal or no data on the effect of parenteral GC use on T2DM. OBJECTIVE: To assess the association between use of parenteral GCs and the risk of receiving a first prescription of a non-insulin antidiabetic drug (NIAD) as a proxy for new onset of T2DM. METHODS: A population based case-control study was performed using the Clinical Practice Research Datalink (CPRD). Cases (n=177,154) were defined as patients >18years of age who had their first ever NIAD prescription between January 1987 and October 2013. Controls were matched by age, gender and general practitioner practice. Conditional logistic regression analyses were used to estimate the risk of NIAD prescription and use of parenteral GCs. Our analyses were statistically adjusted for lifestyle factors, comorbidities and concomitant drug use. RESULTS: Although this study confirmed that oral GCs increases the risk of receiving a first prescription of a NIAD (OR 2.63 [95% CI 2.53-2.73]), there was no association between the use of parenterally administered GCs and the risk of receiving a first prescription of a NIAD (OR 0.88 [95% CI 0.76-1.02]). The number of GC prescriptions was not associated with risk of new onset T2DM compared to no parenteral GCs use; neither the type of GC. CONCLUSION: Our study does not demonstrate an association between the use of parenteral GCs and the risk of new onset of T2DM. |
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| 組織名 | Department of Pharmacy, Sint Maartenskliniek, Nijmegen, The Netherlands.;Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute of;Pharmaceutical Sciences, Utrecht University, Utrecht, Netherlands; Department of;Epidemiology, Care and Public Health Research Institute (CAPHRI), Maastricht;University, Maastricht, the Netherlands.;Pharmaceutical Sciences, Utrecht University, Utrecht, Netherlands.;University, Maastricht, the Netherlands; Department of Clinical Pharmacy and;Toxicology, Maastricht University Medical Centre+, Maastricht, Netherlands.;Electronic address: f.devries@uu.nl.;Department of Pharmacy, Sint Maartenskliniek, Nijmegen, The Netherlands;;Department of Pharmacy, Radboud University Medical Center, Nijmegen, The;Netherlands. |
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