| アブストラクト | BACKGROUND: In Italy, the bacterial lysate OM-85 (Broncho-Vaxom((R)), Broncho-Munal((R)), Ommunal((R)), Paxoral((R)), Vaxoral((R))) is registered for the prophylaxis of recurrent respiratory tract infections (RTIs) in adults and children above one year of age, but there are limited data on its use in the paediatric population. We aim to estimate the impact of OM-85 treatment on RTIs and antibiotic prescriptions in children. METHODS: This study included children aged 1 to 14 years enrolled in Pedianet, a paediatric general practice research database, from January 2007 to June 2017, having at least one prescription of OM-85. Children with less than 12 months of follow-up before (PRE period) and after (POST period) the OM-85 prescription were excluded. The frequency of antibiotic prescriptions and the frequency of RTI episodes in the PRE and POST periods were compared through the post-hoc test. Subgroup analysis was performed in children with recurrent RTIs. RESULTS: 1091 children received 1382 OM-85 prescriptions for a total follow-up of 619,525.5 person-years. Overall, antibiotic prescriptions decreased from a mean of 2.8 (SD (standard deviation) 2.7) prescriptions in the PRE period to a mean of 2.2 (SD 2.6) prescriptions in the POST period (p < 0.0001). RTIs decreased from a mean of 3.4 (SD 2.9) episodes in the PRE period to a mean of 2.5 (SD 2.6) episodes in the POST period (p < 0.0001). No change in antibiotic class was noted, and co-amoxiclav remained the preferred therapy in 28% of cases, followed by amoxicillin. These results were confirmed among children with recurrent RTIs. CONCLUSIONS: OM-85 is effective in preventing both antibiotic prescriptions and RTIs in children. |
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| ジャーナル名 | International journal of environmental research and public health |
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| 投稿日 | 2021/7/3 |
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| 投稿者 | Cantarutti, Anna; Barbieri, Elisa; Scamarcia, Antonio; Cantarutti, Luigi; Canova, Cristina; Giaquinto, Carlo |
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| 組織名 | Unit of Biostatistics, Epidemiology and Public Health, Department of Statistics;and Quantitative Methods, University of Milano-Bicocca, 20126 Milan, Italy.;National Centre for Healthcare Research and Pharmacoepidemiology, Department of;Statistics and Quantitative Methods, University of Milano-Bicocca, 20126 Milan,;Italy.;Societa Servizi Telematici-Pedianet, 35121 Padua, Italy.;Division of Pediatric Infectious Diseases, Department for Woman and Child Health,;University of Padua, 35128 Padua, Italy.;Unit of Biostatistics, Epidemiology and Public Health, Department of Cardiac,;Thoracic, Vascular Sciences and Public Health, University of Padova, 35128;Padova, Italy. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/34206831/ |
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