| アブストラクト | BACKGROUND: Reports of allergic reactions to coronavirus disease 2019 (COVID-19) vaccines, coupled with an "infodemic" of misinformation, carry the potential to undermine confidence in the COVID-19 vaccines. However, no attempts have been made to comprehensively synthesize the literature on how allergic disease and fear of allergic reactions to the vaccines contribute to hesitancy. OBJECTIVES: Our aim was to review the academic and gray literature on COVID-19 vaccine hesitancy and allergic reactions. METHODS: We searched 4 databases (CINAHL, PsycINFO, MEDLINE, and Embase) using a search strategy developed by content and methodologic experts. No restrictions were applied regarding COVID-19 vaccine type, country of study, or patient age. Eligible articles were restricted to 10 languages. RESULTS: Of the 1385 unique records retrieved from our search, 60 articles (4.3%) were included. Allergic reactions to the COVID-19 vaccine were rare but slightly more common in individuals with a history of allergic disease. A fifth of the studies (13 of 60 [22%]) discussed vaccine hesitancy due to possibility of an allergic reaction. Additionally, the present review identified research on details of vaccine-related anaphylaxis (eg, a mean and median [excluding clinical trial data] of 12.4 and 5 cases per million doses, respectively) and allergic reactions (eg, a mean and median [excluding clinical trial data] of 489 and 528 cases per million doses, respectively). CONCLUSION: COVID-19 vaccine acceptance among individuals living with allergy and among those with no history of allergic disease may be affected by fear of an allergic reaction. Despite the low incidence of allergic reactions to the COVID-19 vaccine, fear of such reactions is one of the most commonly cited concerns reported in the literature. |
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| 投稿者 | Batac, Ayel Luis R; Merrill, Kaitlyn A; Askin, Nicole; Golding, Michael A; Abrams, Elissa M; Begin, Philippe; Ben-Shoshan, Moshe; Ladouceur, Erika; Roos, Leslie E; Protudjer, Vladan; Protudjer, Jennifer L P |
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| 組織名 | Department of Pediatrics and Child Health, Max Rady College of Medicine, Rady;Faculty of Health Sciences.;Children's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada.;WRHA Virtual Library, Winnipeg, Manitoba, Canada.;Division of Allergy and Immunology, Department of Pediatrics, Faculty of;Medicine, University of British Columbia, Vancouver, British Columbia, Canada.;Division of Allergy, Department of Pediatrics, Centre Hospitalier Universitaire;Sainte-Justine, Montreal, Quebec, Canada.;Division of Allergy, Department of Medicine, Centre Hospitalier de l'Universite;de Montreal, Montreal, Quebec, Canada.;Division of Pediatric Allergy, Clinical Immunology, and Dermatology, Department;of Pediatrics, Montreal Children's Hospital, Montreal, Quebec, Canada.;Centre for Outcomes Research and Evaluation, Research Institute of the McGill;University Health Centre, Montreal, Quebec, Canada.;Department of Epidemiology, Biostatistics, and Occupational Health, School of;Population and Global Health, Montreal, Quebec, Canada.;Division of Experimental Medicine, Department of Medicine, School of Medicine,;Faculty of Medicine and Health Sciences, McGill University, Montreal, Quebec,;Canada.;Science for All Audiences, Toronto, Ontario, Canada.;Department of Psychology, Faculty of Arts, Winnipeg, Manitoba, Canada.;College of Nursing, Rady Faculty of Health Sciences, Winnipeg, Manitoba, Canada.;Department of Food and Human Nutritional Sciences, Faculty of Agricultural and;Food Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.;George and Fay Yee Centre for Healthcare Innovation, Winnipeg, Manitoba, Canada.;Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden. |
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