| アブストラクト | OBJECTIVES: Weight loss is conditionally recommended for gout management; however, its impact on incident gout and recurrent gout flares among overweight and obese individuals remains unknown. We aimed to investigate the relationship between weight loss rate following the initiation of anti-obesity medications and the risk of incident gout and recurrent gout flares among overweight/obese individuals. METHODS: Using data from The Health Improvement Network, we selected individuals aged 18 and older who were overweight or obese and started anti-obesity medication. We emulated a target trial to examine the association of different weight loss rates, slow (2-5%), moderate (5-10%), or fast (>/=10%), within the first year of treatment with incident gout and recurrent gout flares during a 5-year follow-up period. RESULTS: Among 131,000 participants without gout starting orlistat, the 5-year risk of incident gout was 1.6% for those with weight gain/stable, compared with 1.5%, 1.3%, and 1.2% for those with slow, moderate, and fast weight loss, respectively. Compared with the weight gain/stable arm, the hazard ratios were 0.91 (95% confidence interval [CI]: 0.81 to 1.01), 0.82 (95%CI: 0.72 to 0.92), and 0.73 (95%CI: 0.62 to 0.86) for slow, moderate and fast rate of weight loss arms, respectively. Similar results were observed for the recurrent gout flares among 3,847 overweight or obese individuals with gout starting orlistat. CONCLUSIONS: A higher rate of weight loss after initiating orlistat within 1-year was associated with lower risks of incident gout and lower rates of recurrent gout flares among overweight or obese people. |
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| 投稿者 | Wei, Jie; Wang, Yilun; Dalbeth, Nicola; Xie, Junqing; Wu, Jing; Zeng, Chao; Lei, Guanghua; Zhang, Yuqing |
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| 組織名 | Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha,;China.;Hunan Key Laboratory of Joint Degeneration and Injury, Changsha, China.;Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment,;Ministry of Education, Xiangya Hospital, Central South University, Changsha,;Department of Epidemiology and Health Statistics, Xiangya School of Public;Health, Central South University, Changsha, China.;Department of Medicine, University of Auckland, Auckland, New Zealand.;Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences,;University of Oxford, Oxford, UK.;National Clinical Research Center for Geriatric Disorders, Xiangya Hospital,;Central South University, Changsha, China.;Division of Rheumatology, Allergy, and Immunology, Department of Medicine,;Massachusetts General Hospital, Harvard Medical School, Boston, USA.;The Mongan Institute, Massachusetts General Hospital, Harvard Medical School,;Boston, USA. |
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