| アブストラクト | One challenge in the development of novel drugs is their interaction with potential off-targets, which can cause unintended side-effects, that can lead to the subsequent withdrawal of approved drugs. At the same time, these off-targets may also present a chance for the repositioning of withdrawn drugs for new indications, which are potentially rare or more severe than the original indication and where certain adverse reactions may be avoidable or tolerable. To enable further insights into this topic, we updated our database Withdrawn by adding pharmacovigilance data from the FDA Adverse Event Reporting System (FAERS), as well as mechanism of action and human disease pathway prediction features for drugs that are or were temporarily withdrawn or discontinued in at least one country. As withdrawal data are still spread over dozens of national websites, we are continuously updating our lists of discontinued or withdrawn drugs and related (off-)targets. Furthermore, new systematic entry points for browsing the data, such as an ATC tree, were added, increasing the accessibility of the database in a user-friendly way. Withdrawn 2.0 is publicly available without the need for registration or login at https://bioinformatics.charite.de/withdrawn_3/index.php. |
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| ジャーナル名 | Nucleic acids research |
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| Pubmed追加日 | 2023/11/17 |
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| 投稿者 | Gallo, Kathleen; Goede, Andrean; Eckert, Oliver-Andreas; Gohlke, Bjoern-Oliver; Preissner, Robert |
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| 組織名 | Charite - Universitatsmedizin Berlin, Institute of Physiology and GB IT, Science;IT, Corporate Member of Freie Universitat Berlin, Berlin Institute of Health,;Humboldt-Universitat zu Berlin, 10117 Berlin, Germany. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/37971295/ |
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